A Genetic Analysis of the Double Cervix Condition in Cattle

Sittmann, K.; Rollins, W. C.; Kendrick, John W.

doi:10.1093/oxfordjournals.jhered.a107016

Cited by 12 publications

(12 citation statements)

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“…However, autosomal translocations usually do not result in phenotypical changes unless they are associated with a loss of genetic material (Rieck 1984). Another possibility is that duplication of the urethra is attributable to a recessive gene with weak penetrance, as in duplication of the cervix in cattle (Fincher and Williams 1926, Bonfert and Mai 1958, Sittman and others 1961). This heifer was inbred and could have inherited a recessive gene, which in the homozygous state may have been responsible for duplication of the urethra.…”

Section: Discussionmentioning

confidence: 99%

Urethral duplication and chromosomal translocation in a Swiss braunvieh heifer

et al. 2000

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As it was urinating, a six-month-old Swiss braunvieh heifer produced a second stream of urine from a fistula that opened on the ventrolateral margin of the left vulval lip. A catheter was introduced into this opening and passed easily into the bladder. Urethrography showed that the fistula joined the urethra in the mid-pelvic region and that a single canal originated from the bladder. Endoscopy confirmed this finding and also revealed a duplication of the vaginal portion of the cervix, a division of the cranial vagina by a septum and a fibrous band in the region of the hymenal ring. Cytogenetic examination revealed reciprocal translocation between chromosomes 20q23 and 22q23. A diagnosis of urethra duplex, duplication of the vaginal portion of the cervix and reciprocal autosomal translocation between chromosomes 20 and 22 was made on the basis of these findings.

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Section: Discussionmentioning

confidence: 99%

Urethral duplication and chromosomal translocation in a Swiss braunvieh heifer

et al. 2000

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“…Differences in incidence between provinces suggested the existence of modifying genes or differences in the linkage disequilibrium with the coat-colour locus (Hanset, 1960). In both Belgian lowland Red herds and in two closely related herds of American Herefords, individual bulls were found to produce offspring with high frequencies of double cervices and, in the Herefords, associated abnormalities of the Müllerian ducts (Hanset, 1959;Sittman et al, 1961).…”

Section: Discussionmentioning

confidence: 99%

“…Longitudinal vaginal septa, unaccompanied by any other structural abnormalities, have been reported in mice (Cunliffe-Beamer & Feldman, 1976), cattle and buffalo (Sittman, Rollins & Kendrick, 1961), horses (Finocchio, Hales & Wolfe, 1968), pigs (Teige, 1957) and people (8 cases: Dougherty & Spencer, 1972). The frequency of affected females was as high as 1 -4% for Danish pigs and 38% for the BALB/cJ inbred strain of mice.…”

Section: Introductionmentioning

confidence: 94%

Studies on the inheritance of vaginal septa in mice, a trait with low penetrance

Shire¹

1984

Reproduction

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Longitudinal vaginal septa were found in 1-3% of females of the BALB/cBy and C57BL/6By inbred strains and their F1, F2 and backcross hybrids. In the CXBJ recombinant-inbred strain over half the females were affected, showing that the parental strains differed at a minimum of 2 loci that increased the risk of septa. Crosses involving CXBJ mice showed that susceptibility could be transmitted by the male parent and suggested that the different genotypes producing low penetrance could be identified. Subline differences in C57BL were marked, the incidence ranging from 1% in C57BL/6By to about 26% in two lines congenic with C57BL/10ScSn. No association was found between incidence and H-2 histocompatibility type. Imperforate vagina occurred at a low frequency in 4 stocks in which septa were regularly found. The minor anomaly was about 15 times more likely than the malformation.

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“…Indeed, a high incidence of 'white heifer disease' was created experimentally by breeding a known carrier to his female offspring (Bennett and others 1973). Another group of Müllerian duct defects was described by Sittmann and others (1961). This collection of defects was restricted to the lower reproductive tract and consisted of a double cervix, incomplete double cervix or vaginal septum.…”

Section: Heifer Number Cervix Uterus Uterine Tube Ovaries Othermentioning

confidence: 98%

“…Again the condition was associated with in‐breeding and characterised within a closed breeding herd. While certain manifestations of the cervical abnormalities and 'white heifer disease' overlapped, Sittmann and others (1961) suggest that the arrest of Müllerian duct fusion which results in malformations of the cervix occurs later in embryonic development than in 'white heifer disease' and that this problem may involve a separate gene from that of 'white heifer disease'. In this study one or both uterine tubes were non‐patent in four animals, one of which also had a non‐patent cervix.…”

Section: Heifer Number Cervix Uterus Uterine Tube Ovaries Othermentioning

confidence: 99%