A Genetic Dissection of Vascular Risk Factors for Cervical Artery Dissection

De Backer, Tine

doi:10.1016/j.jacc.2023.08.011

Cited by 2 publications

References 17 publications

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Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection

Xu,

Li,

Chen

et al. 2024

American Journal of Hypertension

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BACKGROUND We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk by employing a 2-sample Mendelian randomization (TSMR) framework. METHODS Utilizing large-scale genome-wide association studies-retrieved data, we employed various Mendelian randomization (MR) techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP’s causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran’s Q statistic. RESULTS The findings highlighted a significant association between elevated systolic BP (SBP; IVW: OR = 3.09, 95% CI: 1.11–8.61, P = 0.031) and increased diastolic BP (DBP; IVW: OR = 2.17, 95% CI: 1.14–6.21, P = 0.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results. CONCLUSIONS The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, which provides genetic evidence for a reduced risk of CAD under BP control.

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Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection

Xu,

Li,

Chen

et al. 2024

American Journal of Hypertension

View full text Add to dashboard Cite

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Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection

Xu,

Chen,

Wang

et al. 2024

Preprint

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Objectives We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk employing a two-sample Mendelian randomization (TSMR) framework. Methods Utilizing large-scale genome-wide association studies (GWAS)-retrieved data, we employed various MR techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP's causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran's Q statistic. Results The findings highlighted a significant association between elevated systolic BP (SBP; IVW: OR = 3.09, 95% CI: 1.11–8.61, p = 0.031) and increased diastolic BP (DBP; IVW: OR = 2.17, 95% CI: 1.14–6.21, p = 0.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results. Conclusions The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, underscoring the importance of effective BP control.

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A Genetic Dissection of Vascular Risk Factors for Cervical Artery Dissection

Cited by 2 publications

References 17 publications

Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection

Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection

Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection

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