2015
DOI: 10.3233/bme-151503
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A genetic filter for cancer classification on gene expression data

Abstract: Abstract. We present a new genetic filter to identify a predictive gene subset for cancer-type classification on gene expression profiles. This approach pursues to not only maximize correlation between selected genes and cancer types but also minimize inter-correlation among selected genes. The proposed genetic filter was tested on well-known leukemia datasets, and significant improvement over previous work was obtained.

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Cited by 8 publications
(5 citation statements)
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“…In future studies, it is anticipated that QC and correction using machine learning will have further improved performance by understanding relationships with other data through methods such as a dimensional reduction technique [35][36][37]. Furthermore, this study may become the basis of leading to practical studies such as the valuation of collected data and prediction of sensor malfunction.…”
Section: Resultsmentioning
confidence: 99%
“…In future studies, it is anticipated that QC and correction using machine learning will have further improved performance by understanding relationships with other data through methods such as a dimensional reduction technique [35][36][37]. Furthermore, this study may become the basis of leading to practical studies such as the valuation of collected data and prediction of sensor malfunction.…”
Section: Resultsmentioning
confidence: 99%
“…Filter-based feature selection [31][32][33] has the advantage of deriving feature subsets by identifying correlations between features within a relatively short time; however, it has the disadvantage that it may be difficult to quantify relevance and redundancy between selected features. In this study, a new fitness function was devised to emphasize the advantages and make up for the disadvantages.…”
Section: Genetic Filtermentioning
confidence: 99%
“…Lastly, filtering method [17] is applied to select those genes that have p-value less than 0.05. This is because p value will determine the significant towards cancer mutation.…”
Section: Figure 3 Step 2 Normalizationmentioning
confidence: 99%