2021
DOI: 10.1093/g3journal/jkab172
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A genetic screen for regulators of muscle morphogenesis inDrosophila

Abstract: The mechanisms that determine the final topology of skeletal muscles remain largely unknown. We have been developing Drosophila body wall musculature as a model to identify and characterize the pathways that control muscle size, shape, and orientation during embryogenesis (Johnson et al., 2013; Williams et al., 2015; Yang et al., 2020a; Yang et al., 2020b). Our working model argues muscle morphogenesis is regulated by (1) extracellular guidance cues that direct muscle cells toward muscle attachment sites, and … Show more

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Cited by 4 publications
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“…For Mendelian diseases, we have relied on genetic screens in model organisms like roundworms ( Caenorhabditis elegans ) ( O’Connell et al . 1998 ), Drosophila ( Ou et al . 2021 ), and mice ( Buchovecky et al .…”
Section: Introductionmentioning
confidence: 99%
“…For Mendelian diseases, we have relied on genetic screens in model organisms like roundworms ( Caenorhabditis elegans ) ( O’Connell et al . 1998 ), Drosophila ( Ou et al . 2021 ), and mice ( Buchovecky et al .…”
Section: Introductionmentioning
confidence: 99%