A genetic study of FGG/FGA‎ mutations effect on D-dimer levels among COVID-19 patients in Jordan

Abstract

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. This study aims to investigate the association between the single nucleotide polymorphisms (SNPs) of fibrinogen genes (FGG/FGA) monitored by the D-Dimer elevated levels in COVID-19 Jordanian patients. Blood samples were collected from 120 participants among which 90 were infected with COVID-19 while the rest 30 were used as healthy controls. The potential association between mutations in the fibrinogen gene and the elevated D-Dimer levels in COVID-19 patients was examined using Multiplex PCR and Sequencing. The results showed a correlation coefficient of 0.378 and a p-value of < 0.00 between D-Dimer levels and Covid-19 status. In addition, the results showed an escalation in COVID-19 incidence in the relevant age group of‏ ‏the study population (r = 0.209, ‎p < 0.022)‎. However, the current findings indicate that there is no link between D-Dimer levels and FGA/FGG mutation. These results suggest that the presence or absence of mutations in the FGA and FGG genes does not significantly affect D-Dimer levels in COVID-19 patients among the Jordanian population. Further study was required to examine the association between other factors and the D-Dimer elevated levels of COVID-19.