2022
DOI: 10.1101/2022.08.22.504778
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A genome-scale metabolic model of Drosophila melanogaster for integrative analysis of brain diseases

Abstract: High conservation of the disease-associated genes between fly and human facilitates the common use of Drosophila melanogaster to study metabolic disorders under controlled laboratory conditions. However, metabolic modeling studies are highly limited for this organism. We here report a comprehensively curated genome-scale metabolic network model of Drosophila using an orthology-based approach. The gene coverage and metabolic information of the orthology-based draft model were expanded via Drosophila-specific KE… Show more

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Cited by 1 publication
(2 citation statements)
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“…The results of our metabolic network analysis not only recapitulated known metabolic functions of individual tissues, but also revealed distinct metabolic network structures across tissues. This information is valuable as currently available GEMs for Drosophila , such as Fruitfly1 25 , FlySilico 23 , and iDrosophila 24 , are not tissue-specific, used for larvae, or used for a specific brain disease model, respectively. Furthermore, while previous GEMs in Drosophila did not consider enzyme constraints, we integrated enzyme kinetics and abundances into each tissue-specific GEM, revealing maximum rate distributions across tissues.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The results of our metabolic network analysis not only recapitulated known metabolic functions of individual tissues, but also revealed distinct metabolic network structures across tissues. This information is valuable as currently available GEMs for Drosophila , such as Fruitfly1 25 , FlySilico 23 , and iDrosophila 24 , are not tissue-specific, used for larvae, or used for a specific brain disease model, respectively. Furthermore, while previous GEMs in Drosophila did not consider enzyme constraints, we integrated enzyme kinetics and abundances into each tissue-specific GEM, revealing maximum rate distributions across tissues.…”
Section: Discussionmentioning
confidence: 99%
“…In Drosophila, several GEMs have been generated to analyze metabolic perturbations in silico. For instance, FlySilico was developed to identify essential amino acids that control larval growth rate 23 and iDrosophila was built to evaluate a fly model of Parkinson's disease 24 . Moreover, Fruitfly1 was reconstructed as a comprehensive generic model based on ortholog and biochemical reactions from the KEGG database 25 .…”
Section: Introductionmentioning
confidence: 99%