2018
DOI: 10.1111/mec.14813
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A genome scan of diversifying selection in Ophiocordyceps zombie‐ant fungi suggests a role for enterotoxins in co‐evolution and host specificity

Abstract: Identification of the genes underlying adaptation sheds light on the biological functions targeted by natural selection. Searches for footprints of positive selection, in the form of rapid amino acid substitutions, and the identification of species-specific genes have proved to be powerful approaches to identifying the genes involved in host specialization in plant-pathogenic fungi. We used an evolutionary comparative genomic approach to identify genes underlying host adaptation in the ant-infecting genus Ophi… Show more

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Cited by 27 publications
(48 citation statements)
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“…A growing body of literature has proposed possible fungal effectors of the ant-manipulating Ophiocordyceps based on genomic, transcriptomic, and metabolomic analyses ( de Bekker et al 2014b , 2015 , 2017a ; Wichadakul et al 2015 ; Kobmoo et al 2018 ). Although phylogenetic and experimental evidence indicate that Ophiocordyceps -ant interactions are species specific ( Kobmoo et al 2012 ; de Bekker et al 2014b ; Araújo et al 2018 ; Sakolrak et al 2018 ), we hypothesized that Ophiocordyceps species share mechanisms to infect and manipulate their hosts as they face similar host and transmission related challenges ( Chetouhi et al 2015 ; Loreto et al 2018 ).…”
Section: Resultsmentioning
confidence: 99%
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“…A growing body of literature has proposed possible fungal effectors of the ant-manipulating Ophiocordyceps based on genomic, transcriptomic, and metabolomic analyses ( de Bekker et al 2014b , 2015 , 2017a ; Wichadakul et al 2015 ; Kobmoo et al 2018 ). Although phylogenetic and experimental evidence indicate that Ophiocordyceps -ant interactions are species specific ( Kobmoo et al 2012 ; de Bekker et al 2014b ; Araújo et al 2018 ; Sakolrak et al 2018 ), we hypothesized that Ophiocordyceps species share mechanisms to infect and manipulate their hosts as they face similar host and transmission related challenges ( Chetouhi et al 2015 ; Loreto et al 2018 ).…”
Section: Resultsmentioning
confidence: 99%
“…Proposed effector-response interactions and conclusions A growing body of literature has proposed possible fungal effectors of the ant-manipulating Ophiocordyceps based on genomic, transcriptomic, and metabolomic analyses (de Bekker et al 2014b(de Bekker et al , 2015(de Bekker et al , 2017aWichadakul et al 2015;Kobmoo et al 2018). Although phylogenetic and experimental evidence indicate that Ophiocordyceps-ant interactions are species specific (Kobmoo et al 2012;de Bekker et al 2014b;Araújo et al 2018;Sakolrak et al 2018), we hypothesized that Ophiocordyceps species share mechanisms to infect and manipulate their hosts as they face similar host and transmission related challenges (Chetouhi et al 2015;Loreto et al 2018). Indeed, we have found transcriptomic and genomic signals during Ophiocordyceps camponoti-floridani manipulation in line with previous work on O. kimflemingiae and other species, indicating several possible common contributors to infection and manipulation.…”
Section: Fungal Secondary Metabolites Involved In Manipulation and Inmentioning
confidence: 99%
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“…Reads shorter than 50 bp were discarded. Processed reads were then initially mapped to the latest version of O. polyrhachis-furcata reference (Kobmoo et al, 2018), thanks to its higher quality (43.25 Mb, 68 scaffolds, N50 ~ 2.9 Mb) compared to those of the two other species (O. camponoti-leonardi: 37.91 Mb, 531 scaffolds, N50 ~ 140 Kb; O camponotisaundersi: 49.26 Mb, 1,700 scaffolds, N50 ~ 102 Kb), using bwa-mem (Li, 2013) with the options - As there were no reference variants, the variant recalibration step was dismissed but the variants were filtered a posteriori with total depth between 700x and 5000x, depth for individual samples > 10, mapping quality > 10, quality normalized by depth > 20, genotyping quality > 50; various corrections for biases related to the difference of quality between reference and variant alleles were also applied. Any SNP overlapping with regions including repeats identified beforehand with RepeatMasker (Smit et al, http://www.repeatmasker.org) was excluded.…”
Section: Mapping and Detection Of Single Nucleotide Polymorphismsmentioning
confidence: 99%
“…For the within-species analyses, the reads from O. camponoti-leonardi and O. camponotisaundersi were mapped to their respective reference (Kobmoo et al, 2018). The same procedures of mapping and variant calling were applied as in O. polyrhachis-furcata above with slightly different filtering (for O. camponoti-leonardi, final SNPs with total depth between 50x and 3000x, mapping quality > 10, quality normalized by depth > 20; for O. camponoti-saundersi, final SNPs with total depth between 50x and 1000x, depth for individual samples > 20, mapping quality > 10, quality normalized by depth > 20).…”
Section: Mapping and Detection Of Single Nucleotide Polymorphismsmentioning
confidence: 99%