2007
DOI: 10.1038/sj.mp.4002012
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A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

Abstract: The genetic basis of bipolar disorder has long been thought to be complex, with the potential involvement of multiple genes, but methods to analyze populations with respect to this complexity have only recently become available. We have carried out a genome-wide association study of bipolar disorder by genotyping over 550 000 single-nucleotide polymorphisms (SNPs) in two independent case-control samples of European origin. The initial association screen was performed using pooled DNA, and selected SNPs were co… Show more

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Cited by 641 publications
(634 citation statements)
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“…The region has been identified in three previous genome scans Fallin et al, 2004;Pato et al, 2004) and by the meta-analysis reported by Segurado et al (Segurado et al, 2003); note that none of these studies considered AAO in their analyses. One of the four genome-wide association studies conducted for bipolar disorder (WTCCC, 2007;Baum et al, 2008, Sklar et al, 2008, the Wellcome Trust Case control consortium, reported moderate evidence for association of bipolar disorder in the 2q14 region (p=10 -6 ). This region however gave no or only weak signals for association in the three other studies.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The region has been identified in three previous genome scans Fallin et al, 2004;Pato et al, 2004) and by the meta-analysis reported by Segurado et al (Segurado et al, 2003); note that none of these studies considered AAO in their analyses. One of the four genome-wide association studies conducted for bipolar disorder (WTCCC, 2007;Baum et al, 2008, Sklar et al, 2008, the Wellcome Trust Case control consortium, reported moderate evidence for association of bipolar disorder in the 2q14 region (p=10 -6 ). This region however gave no or only weak signals for association in the three other studies.…”
Section: Discussionmentioning
confidence: 99%
“…However, such findings have not always been replicated (Craddock and Forty, 2006), and meta-analysis of 18 genome scans on bipolar disorder failed to yield statistically significant linkage results (Segurado et al, 2003). Recently, three groups have performed independent whole genome association studies of bipolar disorder (WTCCC, 2007;Baum et al, 2008;Sklar et al, 2008), but the studies agreed only for a limited number of regions and for the ankyrin 3 (ANK3) O'Donovan et al, 2009;Smith et al, 2009;Schulze et al, 2009;Scott et al, 2009;Moskvina et al, 2009) gene and alpha 1C subunit of the voltage-dependent calcium channel (CACNA1C) O'Donovan et al, 2009) genes. This may reflect clinical and genetic heterogeneity of bipolar disorder and lack of a consensus definition for the affected phenotype Leboyer, 2003 A "symptom candidate approach" has been proposed to disentangle the genetic and clinical heterogeneity of BP, and age at onset (AAO) has proved to be a relevant candidate symptom .…”
Section: Introductionmentioning
confidence: 99%
“…In addition, controls who met lifetime criteria for recurrent major depressive disorder with functional impairment on the basis of their responses to depression items were excluded. The second control sample and the control samples utilized in Baum et al 16 were selected from the same larger group of controls collected by KN and may overlap considerably.…”
Section: Nimh Control Samplesmentioning
confidence: 99%
“…Although a remaining problem with large GWA studies is the cost of genotyping, one recent study provided evidence that sample pooling strategies might help to overcome this issue [70]. Furthermore, as the trends observed in recent GWA studies are anticipated to continue, chips with over 1,000,000 million SNPs have recently been launched with an improvement in genotying accuracies and reduced cost.…”
Section: Current and Future Directionsmentioning
confidence: 99%