A genome-wide association study of antidepressant-induced mania

Zai, Clement C.; Squassina, Alessio; Tiwari, Arun; Pisanu, Claudia; Pinna, Marco; Pinna, Federica; Meloni, Anna; Paribello, Pasquale; Carpiniello, Bernardo; Tondo, Leonardo; Frye, Mark A.; Biernacka, Joanna M.; Coombes, Brandon J.; Kennedy, James L.; Manchia, Mirko

doi:10.1016/j.pnpbp.2023.110800

Cited by 5 publications

(1 citation statement)

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“…Similar to recent publications [ 27 , 28 ], our GWAS did not identify any genome-wide significant variants. The top locus in our GWAS was an intronic variant in RNA binding fox-1 homolog 1 ( RBFOX1 ), a gene highly expressed in the brain.…”

Section: Discussionsupporting

confidence: 88%

Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder

Nuñez,

Coombes,

Beaupre

et al. 2024

Transl Psychiatry

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There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for the depressive phase of bipolar disorder (BD) with oftentimes, an inadequate treatment response and or clinical concern for mood destabilization. This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in BD. We conducted a genome-wide association study (GWAS) and polygenic score analysis of TEM and tested its association in a subset of BD-type I patients treated with SSRIs or SNRIs. Our results did not identify any genome-wide significant variants although, we found that a higher polygenic score (PGS) for antidepressant response in MDD was associated with higher odds of TEM in BD. Future studies with larger transdiagnostic depressed cohorts treated with antidepressants are encouraged to identify a neurobiological mechanism associated with a spectrum of depression improvement from response to emergent mania.

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Section: Discussionsupporting

confidence: 88%