2023
DOI: 10.3390/ijms24021278
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A Genome-Wide Functional Screen Identifies Enhancer and Protective Genes for Amyloid Beta-Peptide Toxicity

Abstract: Alzheimer’s disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, we carried out a genome-wide screen in Saccharomyces cerevisiae, using a library of 5154 gene knock-out strains expressing Aβ1–42. We identified 81 mammalian orthologue genes that enhance Aβ1–42 toxicity, while 157 were protective. Next, we performed interactome and text-mining studies to increase th… Show more

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Cited by 2 publications
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“…However, the Surf4 gene stands out as a calcium entry regulator that has been shown to increase the toxicity of amyloid protein, a factor in AD. 11 The discovery of Surf4 may lead to the development of new therapeutic targets for treating AD. The study paves the way for additional investigation into figuring out how much Surf4 and other genes contribute to the development of the disease and how those genes might be targeted to stop or slow it down.…”
Section: New Ad-regulating Genes Discovered: Implications For Therape...mentioning
confidence: 99%
“…However, the Surf4 gene stands out as a calcium entry regulator that has been shown to increase the toxicity of amyloid protein, a factor in AD. 11 The discovery of Surf4 may lead to the development of new therapeutic targets for treating AD. The study paves the way for additional investigation into figuring out how much Surf4 and other genes contribute to the development of the disease and how those genes might be targeted to stop or slow it down.…”
Section: New Ad-regulating Genes Discovered: Implications For Therape...mentioning
confidence: 99%