A genotoxicological study of the new local anesthetic carbamate derivatives Carbisocaine, heptacaine and pentacaine

Siekel, P.

doi:10.1002/jat.2550100403

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…In addition, the anaesthetic benzocaine was found not to be genotoxic in Nile tilapia fish (Gontijo et al 2003). On the other hand, Siekel (1990) reported a genotoxic effect of carbisocaine in Euglena gracilis, but not in Salmonella typhimurium, Escherichia coli and D. melanogaster. These reports on procaine analogues actually indicate the absence of any relevant genotoxic effects of this group of compounds.…”

Section: Discussionmentioning

confidence: 94%

“…Other procaine analogues, all typically used as local anaesthetics in humans, have been tested for genotoxicity and mutagenicity in different organisms. There has been no evidence of articaine being genotoxic to mammals (Leuschner and Leblanc 1999) or of heptacaine and pentacaine being genotoxic to some bacteria and Drosophila melanogaster (Siekel 1990). Cocaine, which is also similar in structure and in function to MS222, was found only to be a weak clastogen in vitro (Yu et al 1999) and not to be mutagenic or carcinogenic in rodents (Salvadori et al 1998).…”

Section: Discussionmentioning

confidence: 95%

“…As benzocaine is structurally similar to MS222 (both are analogues of procaine), the expectation is that MS222 is likewise non-genotoxic for fish. However, another procaine analogue, carbisocaine, has been shown to have genotoxic activity (Siekel 1990). These results suggests that each analogue may have to be tested individually to determine its genotoxicity, or lack thereof.…”

Section: Introductionmentioning

confidence: 97%

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MS222 does not induce primary DNA damage in fish

et al. 2007

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The genotoxicity of the anaesthetic MS222 (tricaine) was analysed in fish under both in vivo and in vitro conditions. Based on results of the single cell gel/ Comet assay, MS222 had no direct genotoxic effect on the experimental fish, indicating that MS222 does not induce primary DNA damage. These results suggest that the use of this important anaesthetic in aquaculture can be considered to be safe in terms of genotoxicity.Keywords Anaesthetic tricaine (ethyl meta-aminobenzoate) AE DNA damage AE Methanesulfonate salt AE MS222 AE Single cell gel (SCG)/Comet assay AE

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 97%

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MS222 does not induce primary DNA damage in fish

et al. 2007

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“…Besides, MS-222 and benzocaine are analogues of procaine (typically used as local anesthetics in humans). Another procaine analogue, carbisocaine, has been shown to have genotoxic activity [ 79 ].…”

Section: Local Anestheticsmentioning

confidence: 99%

Genotoxicity of Anesthetics EvaluatedIn Vivo(Animals)

Braz

Karahalıl

2015

BioMed Research International

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The anesthesia has been improved all over the years. However, it can have impact on health, in both patients and animals anesthetized, as well as professionals exposed to inhaled anesthetics. There is continuing effort to understand the possible effects of anesthetics at molecular levels. Knowing the effects of anesthetic agents on genetic material could be a valuable basic support to better understand the possible mechanisms of these agents. Thus, the purpose of this review is to provide an overview on the genotoxic potential, evaluated in animal models, of many anesthetics that have already been used and those currently used in anesthesia.

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“…Skin contact with contaminated surfaces can lead to a significant additional damage to a human body. This is an equivalent to inhalation of toxic substances [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The estimation of formaldehyde concentration in indoor air

2018

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This article is devoted to the measurement of formaldehyde emissions from furniture materials in the classes of St. Petersburg Polytechnic University and kindergartens. An important task of society is to preserve the health of children and students, since they spend a large amount of time in public buildings. The safety of indoor air depends from the materials of which the finishing materials and furniture are made. Formaldehyde is a priority hazardous substance released into the air of confined spaces. Studies were conducted not only for the amount of formaldehyde in the air in the room, but also for the materials from which the furniture was made. Small-sized installation was made for sampling formaldehyde emissions from furniture materials. These emissions were investigated by the photometric method with acetyl acetone reagent. The installation can be used to study the emissions parameters of other components that can be separated from finishing materials and furniture.

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A genotoxicological study of the new local anesthetic carbamate derivatives Carbisocaine, heptacaine and pentacaine

Cited by 7 publications

References 17 publications

MS222 does not induce primary DNA damage in fish

MS222 does not induce primary DNA damage in fish

Genotoxicity of Anesthetics EvaluatedIn Vivo(Animals)

The estimation of formaldehyde concentration in indoor air

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