A Gentleman with Anemia and Cholestasis

Abstract

Primary sclerosing cholangitis is a rare cause of cholestasis caused by progressive inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts leading to multifocal ductal strictures. Herein, we report a case of primary sclerosing cholangitis and inflammatory bowel disease. The concomitant diagnosis of these two diseases is not typical. The management includes the treatment of inflammatory bowel disease and potential complications of primary sclerosing cholangitis, including dominant strictures of bile duct, portal hypertension, gallbladder diseases, cholangiocarcinoma, and colonoscopic surveillance.

Cirrhosis-induced oxidative stress in erythrocytes: The therapeutic potential of taurine

“…5 ). This finding is in line with other studies that indicate microcytic anemia as a prevalent type of morphological change of RBCs in cirrhosis [ 112 ]. On the other hand, detecting a significant number of polychromasia erythrocytes was another interesting finding that was detected 28 and 42 days after BDL induction ( Fig.…”

“…On the other hand, oxidative stress and its associated complications could play a significant role in this situation [ 11 ]. Several case reports of cholestasis/cirrhosis-induced anemia have been published [ 112 - 114 ]. Hypochromic microcytic anemia seems to be humans’ most prevalent phenotype of cholestasis/cirrhosis-induced anemia [ 112 ].…”

“…Several case reports of cholestasis/cirrhosis-induced anemia have been published [ 112 - 114 ]. Hypochromic microcytic anemia seems to be humans’ most prevalent phenotype of cholestasis/cirrhosis-induced anemia [ 112 ]. In the current study, we detected microcytic hypochromic RBCs in the BDL rats 42 days after the BDL operation ( Fig.…”

“…The mechanism(s) of releasing such erythrocytes in the current model is ambiguous and warrants further studies. Low hemoglobin levels (e.g., 6 g/dl) have also been reported in cholestatic patients with anemia [ 112 ]. As mentioned, oxidative stress and its associated complications play an essential role in erythrocyte damage in cirrhosis.…”