A ghost of retrieval past: a functional network of alpha EEG related to source memory in elderly humans

Luber, Bruce; Habeck, Chris; Trott, Charlotte T.; Friedman, David; Moeller, James R.

doi:10.1016/j.cogbrainres.2004.02.004

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…The stimuli were all short words in common use and the task was to remember if they had occurred earlier in the paradigm. Our finding that flicker close to 10 Hz enhanced this episodic recognition memory parallels the observation that memory tasks which emphasise episodic memory elicit EEG alpha synchronization [ 8 , 9 ]. A plausible mechanism for this enhancement is that flicker-induced rhythmic EEG activity may increase "gain" within recurrent cortico-cortical and cortico-thalamic loops [ 40 , 41 ].…”

Section: Discussionsupporting

confidence: 84%

“…The principal electroencephalographic (EEG) rhythmic slow activity (RSA) – the 10–12 Hz alpha rhythm – relates to memory functions in healthy adults [ 1 - 7 ]. Alpha power may relate particularly to episodic memory [ 8 , 9 ]. It diminishes in old age [ 10 ] and in Alzheimer's disease [ 11 - 14 ], but anti-dementia drugs can increase it [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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10 Hz flicker improves recognition memory in older people

Williams¹,

Ramaswamy

Oulhaj³

2006

BMC Neurosci

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Background: 10 Hz electroencephalographic (EEG) alpha rhythms correlate with memory performance. Alpha and memory decline in older people. We wished to test if alpha-like EEG activity contributes to memory formation. Flicker can elicit alpha-like EEG activity. We tested if alpha-frequency flicker enhances memory in older people. Pariticpants aged 67-92 identified short words that followed 1 s of flicker at 9.0 Hz, 9.5 Hz, 10.0 Hz, 10.2 Hz, 10.5 Hz, 11.0 Hz, 11.5 Hz or 500 Hz. A few minutes later, we tested participants' recognition of the words (without flicker).

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

10 Hz flicker improves recognition memory in older people

Williams¹,

Ramaswamy

Oulhaj³

2006

BMC Neurosci

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“…These findings suggest that the poorer noncontent memory performances of both MCI groups could reflect the impact of executive functioning deficits. In addition, the medial temporal lobes, which show early pathologic changes in persons with AD that correspond with content memory impairment (Braak & Braak, 1991, 1997), collaborate closely with areas of the frontal lobe in performing successful memory operations (Luber, Habeck, Trott, Friedman, & Moeller, 2004; Okuda et al, 1998; Ranganath & Knight, 2003). Therefore, the noncontent memory deficits of the amnestic MCI group could also reflect breakdown in the interactions between the medial temporal and frontal lobe systems.…”

Section: Discussionmentioning

confidence: 99%

Characterizing multiple memory deficits and their relation to everyday functioning in individuals with mild cognitive impairment.

Schmitter‐Edgecombe¹,

Woo²,

Greeley³

2009

Neuropsychology

217

202

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The authors evaluated multiple memory processes and explored their contributions to everyday functional limitations in persons with mild cognitive impairment (MCI). Participants included individuals with amnestic MCI, nonamnestic MCI, and healthy older adults. As expected, the amnestic MCI group performed more poorly than the control and nonamnestic MCI groups on a content memory measure. Both MCI groups, however, performed more poorly than controls on the noncontent memory measures of prospective memory, temporal order memory, and source memory. Informants also reported that the MCI groups were experiencing greater difficulty than controls completing instrumental activities of daily living (IADLs). Noncontent memory measures were found to make an independent contribution to IADL performances over and above that of content memory. These findings demonstrate that impairments in memory beyond the traditionally assessed content memory are present in individuals with amnestic MCI and with nonamnestic MCI. The results further show that these noncontent memory processes, which have been linked with executive functioning, play a role in supporting IADLs.

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“…Forward application of experimentally derived covariance patterns from 1 group to another has proven useful in exploring potential functional topographies. For example, an alpha EEG topography related to performance of an episodic memory task in a group of young adults was found to also be present in a group of elderly adults (Luber et al 2004). In the present case, Habeck et al (2004) found an fMRI covariance network whose expression decreased over the course of sleep deprivation.…”

Section: Discussionmentioning

confidence: 99%

Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation

Luber¹,

Stanford²,

Bulow³

et al. 2008

Cerebral Cortex

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Repetitive transcranial magnetic stimulation (rTMS) was applied to test the role of selected cortical regions in remediating sleep-deprivation-induced deficits in visual working memory (WM) performance. Three rTMS targets were chosen using a functional magnetic resonance imaging (fMRI)-identified network associated with sleep-deprivation-induced WM performance impairment: 2 regions from the network (upper left middle occipital gyrus and midline parietal cortex) and 1 nonnetwork region (lower left middle occipital gyrus). Fifteen participants underwent total sleep deprivation for 48 h. rTMS was applied at 5 Hz during a WM task in a within-subject sham-controlled design. The rTMS to the upper-middle occipital site resulted in a reduction of the sleep-induced reaction time deficit without a corresponding decrease in accuracy, whereas stimulation at the other sites did not. Each subject had undergone fMRI scanning while performing the task both pre- and postsleep deprivation, and the degree to which each individual activated the fMRI network was measured. The degree of performance enhancement with upper-middle occipital rTMS correlated with the degree to which each individual failed to sustain network activation. No effects were found in a subset of participants who performed the same rTMS procedure after recovering from sleep deprivation, suggesting that the performance enhancements seen following sleep deprivation were state dependent.

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A ghost of retrieval past: a functional network of alpha EEG related to source memory in elderly humans

Cited by 7 publications

References 27 publications

10 Hz flicker improves recognition memory in older people

10 Hz flicker improves recognition memory in older people

Characterizing multiple memory deficits and their relation to everyday functioning in individuals with mild cognitive impairment.

Remediation of Sleep-Deprivation-Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation

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