A Giant Anorectal Condyloma Is Not Synonym of Malignancy

Bessi, Meriem El; Dougaz, Mohamed Wejih; Jones, M.; Jerraya, Hichem; Dziri, Chadli

doi:10.1007/s12029-018-00189-3

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…An estimated prevalence of 0.1% has been reported in the general population, with the condition usually presenting between the 4th and 6 th decades of life[ 3 , 5 ]. In the latest case series, the male-to-female ratio was reported as 2.7:1, with patients ranging in age from 24 to 77 years old and a mean age of 43.9 years.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of penile giant condyloma acuminatum with spontaneous prepuce perforation: A case report

Hsu,

Yu,

et al. 2023

World J Clin Cases

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Time series analysis is a valuable tool in epidemiology that complements the classical epidemiological models in two different ways: Prediction and forecast. Prediction is related to explaining past and current data based on various internal and external influences that may or may not have a causative role. Forecasting is an exploration of the possible future values based on the predictive ability of the model and hypothesized future values of the external and/or internal influences. The time series analysis approach has the advantage of being easier to use (in the cases of more straightforward and linear models such as Auto-Regressive Integrated Moving Average). Still, it is limited in forecasting time, unlike the classical models such as Susceptible-Exposed-Infectious-Removed. Its applicability in forecasting comes from its better accuracy for short-term prediction. In its basic form, it does not assume much theoretical knowledge of the mechanisms of spreading and mutating pathogens or the reaction of people and regulatory structures (governments, companies, etc. ). Instead, it estimates from the data directly. Its predictive ability allows testing hypotheses for different factors that positively or negatively contribute to the pandemic spread; be it school closures, emerging variants, etc. It can be used in mortality or hospital risk estimation from new cases, seroprevalence studies, assessing properties of emerging variants, and estimating excess mortality and its relationship with a pandemic.

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Section: Discussionmentioning

confidence: 99%

Unusual presentation of penile giant condyloma acuminatum with spontaneous prepuce perforation: A case report

Hsu,

Yu,

et al. 2023

World J Clin Cases

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“…Since the first description by Abraham Buschke and Ludwig Löwenstein back in 1925 [7][8] , the giant condyloma acuminatum (GCA) and Buschke-Löwenstein tumor (BLT) have become synonymous [9] . It is considered part of a spectrum between a classic condyloma acuminata and a squamous cell carcinoma, where it is always preceded by a classic carcinoma acuminata and presenting a potential risk of transformation to a squamous cell carcinoma, sharing both properties, which make their differentiation difficult [10] . It is a sexually transmitted disease that presents an incidence of 0.1% among sexually active people, predominating in males in a ratio of 2.7:1, with a mean age of presentation of 45 years [11][12] .…”

Section: Discussionmentioning

confidence: 99%

Giant Condyloma of Bushke-Löwenstein (GCBL) in Pregnancy: A Case Report

Delgado Macías,

Varela Barraza,

Sánchez Terán

et al. 2023

ijirms

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We present a case of Giant condyloma of Bushke-Löwenstein (GCBL) in a 15-year-old pregnant woman from the Tarahumara ethnic group. GCBL is a rare sexually transmitted disease caused by the the Human Papillomavirus (HPV) with a high risk of malignant transformation. Surgical resection is the main treatment, but managing GCBL during pregnancy requires careful consideration. This case highlights a rare and challenging condition that shares features with both classic condyloma acuminata and squamous cell carcinoma, making its differentiation difficult and the importance of comprehensive sexual education, culturally sensitive healthcare, and follow-up care in underserved communities. Challenges in post-surgical monitoring and limited knowledge of perinatal outcomes underscore the need for increased awareness, prevention, and early detection strategies, including HPV vaccination.

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“…The lack of standardized diagnostic criteria makes it difficult to establish a precise incidence and prevalence of the GCA, reporting several cases in isolation [ 7 ]; however, a prevalence of 0.1% of the general population is estimated [ 8 ], and an age of presentation between the 4th and 6th decade of life has been suggested [ 1 ]. Several cases have also been described in pediatric age range [ 9 ].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…El Bessi et al have reported the use of neoadjuvant chemotherapy followed by abdominoperineal resection with negative margins and reconstruction in GCA that shows foci of SCC at diagnosis, and this suggests that abdominoperineal resection with or without reconstruction is also considered an option when faced with recurrence [ 8 ].…”

Section: Clinical Managementmentioning

confidence: 99%

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

Condoy

Acuña-Pinzón

Chavarría-Chavira

et al. 2021

Infectious Diseases in Obstetrics and Gynecology

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Giant condyloma acuminatum (GCA) or Buschke-Loewenstein tumor is a rare disease, with an estimated prevalence of 0.1%. It was initially described in 1896 by Buschke and later in 1925 by Buschke and Loewenstein. Classic condyloma acuminata (CCA) and squamous cell carcinoma (SCC) were initially described as different entities. These three entities are currently considered to correspond to the same spectrum of different but not exclusive malignant transformations, associated with multiple risk factors such infection by human papilloma virus (HPV), immunodeficiencies, poor hygiene, multiple sexual partners, and chronic genital infections. HPV subtypes 6 and 11 are associated with 90% of GCA. It presents as a cauliflower-like tumor in the genital region with bad odor, bleeding, and local infection, differential diagnosis with multiple conditions should be considered, and sexually transmitted diseases should always be investigated. GCA has a higher rate of malignant transformation than CCA and tends to infiltrate adjacent soft tissues. The therapeutic approach is controversial but is considered that the resection with free edges is the gold standard and can be combined with adjuncts. The recurrence rate is high. Overall mortality is 21% and is associated with morbidity caused by recurrences. Imiquimod cream 5% has recently shown good results as monotherapy and in combination with ablative and surgical treatments. The quality of life is diminished in patients with this condition. In this review, we address the different aspects of this rare entity including the therapeutic approach.

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A Giant Anorectal Condyloma Is Not Synonym of Malignancy

Cited by 7 publications

References 11 publications

Unusual presentation of penile giant condyloma acuminatum with spontaneous prepuce perforation: A case report

Unusual presentation of penile giant condyloma acuminatum with spontaneous prepuce perforation: A case report

Giant Condyloma of Bushke-Löwenstein (GCBL) in Pregnancy: A Case Report

Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an Unusual Disease and Difficult to Manage

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