A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child: A Case Report

Abstract

A case of two fibrotic lesions of the oral mucosa in a 17-month-old African-American female is reported. Both lesions occurred on the anterior maxilla, one lesion pedunculated on the buccal attached gingiva and the other lesion sessile on the palate. Histological examination characterized the buccal lesion as focal fibrous hyperplasia (FFH) and the palatal lesion as a giant cell fibroma (GCF). A case is made for continuing the consideration of GCF as a histologically distinct entity from FFH but that no difference in clinical impact between the two lesions exists.

Giant Cell Fibroma in a Two-Year-Old Child

“…The giant cell fibroma is a benign fibrous tumor and it is most prevalent amongst the second and third decade of life [5–7], representing an average of 5% of all biopsied fibrous lesions [4, 9, 15] and around 1% of the total accessions in biopsy services [4, 9]. …”

“…The giant cell fibroma usually occurs at young age, and it is more common in the second and third decades of life [5–7]. The prevalence is reported to be high in Caucasians with a slight female predilection [4, 8].…”

“…When present, the inflammatory infiltrate is mono- and polimorfonuclear [1, 10, 11]. Giant cell fibroma could be diagnosed only on histopathological examination [5, 13]. …”

Giant Cell Fibroma in a Paediatric Patient: A Rare Case Report

“…First reported by Weathers and Callihan in 1974, GCF if found predominantly in Caucasians under the age of 30 years with slight female predilection [1]. Its name is attributed to the characteristic histologic presentation, where there is presence of large multinucleated fibroblasts that tend to occur in close proximity to the overlying epithelium.…”

Giant Cell Fibroma: A Case Report with Immunohistochemical Markers

“…Giant cell fibromas have equal sex distribution in first three decades of life [2]. They are most often seen in Caucasians [3]. Generally, fibrous hyperplasias are reactive lesions rather than neoplastic proliferations.…”