A Giant Tumefactive Virchow-Robin Space: A Rare Cause of a Homonymous Quadrantanopia

Rivet, Alain; Gauthier, Anne‐Sophie; Chatain, Marion; Billon-Grand, Romain; Thines, L.; Delbosc, B.

doi:10.1097/wno.0000000000000478

Cited by 5 publications

(10 citation statements)

References 8 publications

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“…Very large MVPVS, referred to as giant or tumefactive MVPVS, can also occur in other regions of the CNS, including the basal ganglia ( Tsutsumi et al, 2011 ), the centrum semiovale ( Taniguchi et al, 2017 ), the hippocampus ( Rivet et al, 2017 ), the corpus callosum ( Manara et al, 2010 ), and the midbrain ( Rocha et al, 2013 ). Several case reports have confirmed the mostly stable nature of these structures ( Ogawa et al, 1995 ; Sawada et al, 1999 ; Flors et al, 2010 ; Tsutsumi et al, 2011 ; Sankararaman et al, 2013 ; Tseng et al, 2013 ; Taniguchi et al, 2017 ), some of them with follow-up periods of up to 7 years ( Manara et al, 2010 ).…”

Section: Resultsmentioning

confidence: 99%

The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis

Okar

Shinohara

et al. 2023

Front. Neurosci.

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ObjectivesPerivascular spaces have been involved in neuroinflammatory and neurodegenerative diseases. Upon a certain size, these spaces can become visible on magnetic resonance imaging (MRI), referred to as enlarged perivascular spaces (EPVS) or MRI-visible perivascular spaces (MVPVS). However, the lack of systematic evidence on etiology and temporal dynamics of MVPVS hampers their diagnostic utility as MRI biomarker. Thus, the goal of this systematic review was to summarize potential etiologies and evolution of MVPVS.MethodsIn a comprehensive literature search, out of 1,488 unique publications, 140 records assessing etiopathogenesis and dynamics of MVPVS were eligible for a qualitative summary. 6 records were included in a meta-analysis to assess the association between MVPVS and brain atrophy.ResultsFour overarching and partly overlapping etiologies of MVPVS have been proposed: (1) Impairment of interstitial fluid circulation, (2) Spiral elongation of arteries, (3) Brain atrophy and/or perivascular myelin loss, and (4) Immune cell accumulation in the perivascular space. The meta-analysis in patients with neuroinflammatory diseases did not support an association between MVPVS and brain volume measures [R: −0.15 (95%-CI −0.40–0.11)]. Based on few and mostly small studies in tumefactive MVPVS and in vascular and neuroinflammatory diseases, temporal evolution of MVPVS is slow.ConclusionCollectively, this study provides high-grade evidence for MVPVS etiopathogenesis and temporal dynamics. Although several potential etiologies for MVPVS emergence have been proposed, they are only partially supported by data. Advanced MRI methods should be employed to further dissect etiopathogenesis and evolution of MVPVS. This can benefit their implementation as an imaging biomarker.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=346564, identifier CRD42022346564.

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Section: Resultsmentioning

confidence: 99%

The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis

Okar

Shinohara

et al. 2023

Front. Neurosci.

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“…In one patient, homonymous quadrantanopsia was attributed to the mass effect of tumefactive VRs [9]. Because of worsening symptoms and enlargement of the tumefactive VRs on MRI 9 months later, this patient underwent cyst fenestration, which resulted in immediate shrinking of the tumefactive VRs with marked clinical improvement [9]. In one other patient, bilateral chorea was attributed to the presence of bilateral tumefactive VRs [37].…”

Section: Literature Searchmentioning

confidence: 96%

“…In 2/5 (40%) patients, symptoms were attributed to the presence of tumefactive VRs. In one patient, homonymous quadrantanopsia was attributed to the mass effect of tumefactive VRs [9]. Because of worsening symptoms and enlargement of the tumefactive VRs on MRI 9 months later, this patient underwent cyst fenestration, which resulted in immediate shrinking of the tumefactive VRs with marked clinical improvement [9].…”

Section: Literature Searchmentioning

confidence: 99%

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Tumefactive Virchow-Robin spaces

Kwee

2019

European Journal of Radiology

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“…Due to its special location, Type III VR spaces are more likely to compress the middle cerebral aqueduct or third ventricle, causing hydrocephalus. In some cases, tumefactive PVS can also cause pulsatile tinnitus ( 56 ), homonymous quadrantanopia ( 57 ), paralysis of the extremities ( 58 ), and reversible focal dystonia ( 59 ). Unlike the small PVS, the brain parenchyma surrounding the giant PVS has an abnormal signal intensity in 32.3% of type II cases and 3.8% of type III cases ( 53 ).…”

Section: Mr Imaging Of Perivascular Spacesmentioning

confidence: 99%

Perivascular Spaces, Glymphatic System and MR

et al. 2022

Front. Neurol.

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The importance of the perivascular space (PVS) as one of the imaging markers of cerebral small vessel disease (CSVD) has been widely appreciated by the neuroradiologists. The PVS surrounds the small blood vessels in the brain and has a signal consistent with the cerebrospinal fluid (CSF) on MR. In a variety of physio-pathological statuses, the PVS may expand. The discovery of the cerebral glymphatic system has provided a revolutionary perspective to elucidate its pathophysiological mechanisms. Research on the function and pathogenesis of this system has become a prevalent topic among neuroradiologists. It is now believed that this system carries out the similar functions as the lymphatic system in other parts of the body and plays an important role in the removal of metabolic waste and the maintenance of homeostatic fluid circulation in the brain. In this article, we will briefly describe the composition of the cerebral glymphatic system, the influencing factors, the MR manifestations of the PVS and the related imaging technological advances. The aim of this research is to provide a reference for future clinical studies of the PVS and glymphatic system.

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A Giant Tumefactive Virchow-Robin Space: A Rare Cause of a Homonymous Quadrantanopia

Cited by 5 publications

References 8 publications

The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis

The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis

Tumefactive Virchow-Robin spaces

Perivascular Spaces, Glymphatic System and MR

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