A given number of effector T cells can only destroy a limited number of target cells in graft rejection

Zheng, Peng; Yang, Yong; Li, Songgang; Li, Jiyu; Gong, Wei; Quan, Zhiwei

doi:10.1016/j.trim.2010.04.008

Cited by 2 publications

(3 citation statements)

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“…The balance to induce tolerance or immunity in adults may be controlled by the number of donor cells infused. A given number of effector T cells could only destroy a limited number of target cells [5]. As compared with animals in foetal or neonatal period, individuals in adult period have more effector T cells to recognize and eliminate invading foreign antigens, including donor cells.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to tolerance induction in neonates, the same number of donor cells results in immunity in adults. Donor cells in adult hosts were entirely eliminated in the periphery by circulating alloreactive T cells before entering into central immune system [3, 5]. On the other hand, alloreactive T cells activate and proliferate in response to the stimulation of donor antigen.…”

Section: Discussionmentioning

confidence: 99%

“…Within 24 h, newborn C57BL/6 mice were inoculated with a total volume of 50 μl spleen cells or cell fraction via the orbital branch of the anterior facial vein. The cell suspension was prepared from F1 mice as previously described [5], and the cell concentration was adjusted in accordance with the requirements. The cells were irradiated or not with 60 Co irradiation at a dose of 3000 rd.…”

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confidence: 99%

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Chimerism but not Neonatal Antigen Exposure Induces Transplant Tolerance

2012

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Acquired transplant tolerance could be readily induced during foetal or neonatal period through donor cell infusion, but it is not the case in adults. This phenomenon has been attributed to the variation of immune system development in neonatal and adult periods. To investigate the role of immature immune system and chimerism in neonatal transplant tolerance, irradiated spleen cells or cell fraction from F1 (BALB/c × C57BL/6) or GFP‐F1 mice were injected intravenously into neonatal C57BL/6 mice to induce tolerance. Irradiated cells or cell fraction could not induce chimerism and transplant tolerance in neonatal mice, even increasing the dose of donor cells to 5 × 107. Living donor cells induced tolerance in neonatal mice, and the quantity of living cells was correlated with the degree of chimerism and tolerance. At the amount of 3 × 107 F1 spleen cells, skin grafts were survived permanently in more than 80% of treated mice. However, the amount of 0.7 × 107 F1 spleen cells could only slightly prolong allografts’ survival. The more donor cells were infused, the higher level of chimerism was achieved, and the higher frequency of alloreactive T cells was deleted. Chimerism is prerequisite for the induction and maintenance of tolerance. Chimerism in long‐term tolerant mice was significantly higher than that in chronic graft rejected mice, with 6.48 ± 4.02% versus 1.41 ± 0.77%. It implies that transplant tolerance depends on the establishment of chimerism, but not on antigen exposure to immature immune system in foetus or neonates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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