A glimpse into the efficacy of alternative therapies in the management of benign prostatic hyperplasia

Ullah, Rahat; Wazir, Junaid; Hossain, Amir; Diallo, Maladho Tanta; Khan, Farhan Ullah; Ihsan, Awais Ullah; Zhou, Xiaohui

doi:10.1007/s00508-020-01692-z

Cited by 5 publications

(3 citation statements)

References 74 publications

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“…Amdii and Al'Shukri (2018) reported that βsitosterol which is one of the major active compounds implicated in the anti-BPH activity of Permixon® (an anti-BPH remedy from Serenoa repens) is abundantly present in the root of Securidaca longipedunculata. The root bark of S. longepedunculata also contains quercetin: a plant phytoconstituent reported as an antioxidant, antiinflammatory, and anti-cancer agent which also inhibits the production of dihydrotestosterone (DHT) (Ullah et al, 2021). DHT production is one of the major factors promoting prostate growth in the pathophysiology of BPH.…”

Section: Discussionmentioning

confidence: 99%

“…Up to 80% of people, particularly those in the underdeveloped and developing World, utilize medicinal plants as their main and first source of healthcare (Oguntibeju, 2019). The usage of medicinal plants has grown in popularity over the years due to the notion that they are a safer (with fewer or no side effects) and less expensive alternative to conventional treatment (Ullah et al, 2021). Ajibade et al, (2005) conducted a study on the ethnomedicine and primary healthcare in Ilorin, Kwara State, Nigeria, and reported that the health-seeking behaviour of people in Kwara state is influenced by the urban areas' socioeconomic situation and cultural values of those in the rural areas.…”

Section: Introductionmentioning

confidence: 99%

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Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria

Gegele,

Ajayi,

Attah

et al. 2023

njpr

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Background: Benign Prostate Hyperplasia (BPH) is a prevalent illness in older men. It is a condition where the prostate becomes enlarged and blocks the ease of urine passage out of the bladder. Around 50% of the male population develops symptoms of BPH around 51- 60 years of age. Current therapeutic management options come with undesirable side effects like weight gain, dizziness, and impotence, hence, the need to source for safer alternatives initiated by the acquisition, recording, and preservation of traditional knowledge of medicinal plants. Objective: This study aims to preserve indigenous knowledge by documenting medicinal herbs in use as therapy for BPH. Materials & method: Ethnobotanical survey was carried out in the study areas through interviews using a semistructured questionnaire. Respondents included elderly members of the communities, herbalists, and practitioners of traditional medicine. Quantitative ethnobotany index (Use value index) and descriptive statistics were used to analyse data. Results: 50 respondents were interviewed, 64% were Herb sellers, 22% TMPs, Others 14%. 37 plants belonging to 24 plant families were mentioned in the survey. Methods of preparation of recipes mentioned includes: maceration (37%), decoctions (52%), juice (7%), infusions and paste/powder (4%). Method of administration were majorly oral route. The plant family Fabaceae (19%) had the highest representation. This was followed by the families Annonaceae (8%), Euphorbiaceae (6%), Curcubitaceae, Menispermaceae, Combretaceae, Apocynaceae and Rutaceae with 5% each. Other plant families represented 42% of the total number of plants mentioned. Conclusion: The study areas are endowed with abundant flora which serves as a repository for researchers in the quest to develop less toxic drugs with little or no side-effect for the management of BPH

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria

Gegele,

Ajayi,

Attah

et al. 2023

njpr

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“…Phytotherapy has been playing an important role in the treatment of BPH for over decades because of its mildness, effectiveness and low adverse effects. Lots of the researchers revealed that several kinds of constituents including the fatty acids, polyphenols, flavonoids, phytosterols, alkanoids may be responsible for BPH inhibitory activities of phytotherapy and the suggested mechanisms includes 5α-reductase inhibitor, α1-adrenoceptor antagonist, aromatase inhibitor, anti-androgen, growth factor inhibitor, and so on [23][24][25]. The special chemical structure of flavonoids makes them have good anti-BPH properties [26].…”

Section: Discussionmentioning

confidence: 99%

Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models

Peng

et al. 2021

BMC Complement Med Ther

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Background The Prinsepia utilis Royle leaves (P. utilis) is a folk herb used for benign prostatic hyperplasia (BPH) control by ethnic minorities for centuries in China with rich in resources. Our previous studies have confirmed the anti-BPH effect of its water extract (QCJ) and the active fraction (Fr. B) separated from the QCJ by animal test. The Fr. B from P. utilis should be a potential candidate for BPH control. Methods In this study, the chemical ingredients of Fr. B were identified by UPLC-QTOF-MS, and quantified by HPLC. Murine animal models were divided into 8 groups, Sham rats, BPH rats, BPH rats administered with finasteride (1 mg/kg), BPH rats administered with Pule’an (460 mg/kg), BPH rats administered with low, high dosage of QCJ (860 mg/kg, 2580 mg/kg respectively), BPH rats administered with low, high dosage of Fr. B (160 mg/kg, 480 mg/kg respectively). The expression of vascular endothelial growth factor (VEGF) in the prostate tissue of rats was tested, and serum levels of dihydrotestosterone (DHT), testosterone (T), estradiol (E2), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and total superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA) in prostate homogenate were measured. One-way ANOVA followed by LSD was used for statistical analysis. Results The BPH rats treated by Fr. B exhibited significant reductions of VEGF and MDA levels, as well as significant increases of SOD, GSH-Px and CAT in the prostate tissue after 28 day administration (P < 0.05). Moreover, Fr. B significantly reduced DHT, DHT/E2 ratio, TNF-α, while increased T levels in serum of BPH rats (P < 0.05). UPLC-QTOF-MS analysis revealed 10 flavonoids as the key constituents of this fraction, which accounted for 54.96% of all substance of Fr. B. The relative contents of compound 1, 2 are 11.1%, 13% in Fr. B respectively. Conclusions These results indicated that the Fr. B obtained from P. utilis alleviated the symptoms of BPH rats through multiple mechanisms including reduction of DHT/E2 ratio, inhibition of growth factor, anti-inflammation and anti-oxidation, in which flavonoids might be the key constituents. It supported the hypothesis that the Fr. B should be further explored as a candidate for BPH patients.

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Herbal nutraceutical treatment of chronic prostatitis–chronic pelvic pain syndrome: a literature review

et al. 2021

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A glimpse into the efficacy of alternative therapies in the management of benign prostatic hyperplasia

Cited by 5 publications

References 74 publications

Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria

Ethnobotanical Study of Plants Used in the Management of Benign Prostate Hyperplasia in Ilorin, Nigeria

Chemical profiles of the active fraction from Prinsepia utilis Royle leaves and its anti-benign prostatic hyperplasia evaluation in animal models

Herbal nutraceutical treatment of chronic prostatitis–chronic pelvic pain syndrome: a literature review

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