A global assessment of phthalates burden and related links to health effects

Katsikantami, Ioanna; Sifakis, Stavros; Tzatzarakis, Manolis; Vakonaki, Elena; Kalantzi, Olga‐Ioanna; Tsatsakis, Aristidis; Rizos, Apostolos K.

doi:10.1016/j.envint.2016.09.013

Cited by 384 publications

(167 citation statements)

References 126 publications

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“…This study is compatible with other studies which agreed that there is a relation between kids' obesity and significant concentrations of phthalates . Other studies stated that newborn males and females are affected by different phthalate compounds and in different ways . For instance, DEHP has a negative effect on female growth, where di‐pentyl phthalate influence males.…”

Section: Impacts Due To Phthalate Exposuresupporting

confidence: 86%

Epoxidized vegetable oil and bio‐based materials as PVC plasticizer

Hosney

Nadiem

Ashour

et al. 2018

J of Applied Polymer Sci

134

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Phthalate esters received a considerable attention owing to its various applications and the harmful health effects resulting from phthalate exposure; thus, finding an alternative to phthalate derivatives became a necessity. Phthalate esters are commonly used as plasticizer in polymer formulation; in particular for poly(vinyl chloride) (PVC) formulation. According to the researches in the last 18 years, epoxidized vegetable oils are one of the alternatives that are strongly encouraged to substitute phthalate esters since they were proven to be valid in various applications, eco-friendly and sustainable resource. However, most of the production practices for epoxidized vegetable oil are via conventional epoxidation that concentrates on a catalyst that is homogeneous and non-reusable. This type of catalyst, however, causes several problems later in the process. Therefore, the selective epoxidation of vegetable oils process requires new catalytic systems that are more aligned with the green chemistry principles. This article reviews the harmful health effects associated with the exposure to phthalate esters products, explains the usage of oleochemicals resources as a substitute to phthalate esters and describes different approaches for the epoxidation of vegetable oils. Finally, it draws attention to the usage of epoxy and bio-based compounds as plasticizers in PVC manufacturing.

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Section: Impacts Due To Phthalate Exposuresupporting

confidence: 86%

Epoxidized vegetable oil and bio‐based materials as PVC plasticizer

Hosney

Nadiem

Ashour

et al. 2018

J of Applied Polymer Sci

134

View full text Add to dashboard Cite

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“…Furthermore, the prolonged iFn responses during persistent chronic inflammation and obesogenesis comprise reciprocal causality between virus susceptibility and obesity (80). additional epigenetic signatures in obesity are likewise altered including methylation and/or histone acetylation levels in genes involved in specific and general metabolic processes, altering thus, the metabolic phenotype of the offspring (81)(82)(83). although no specific therapy exists to block the effects of these factors, recognizing the high risk and anticipating inflammation-associated complications of adipokine release is an important part of optimal patient management.…”

Section: Obesity and Inflammationmentioning

confidence: 99%

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

et al. 2020

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“…They are broadly used in plastics to make them more malleable. 1 Di (2-ethylhexyl) phthalate (DEHP) as one of the most commonly used phthalates is a synthetic chemical substance which is used in a large variety of medical devices such as intravenous bags and tubing, blood bags, and peritoneal dialysis bags. It is also used in manufacturing of consumer products such as packed food.…”

Section: Introductionmentioning

confidence: 99%

Di (2‐ethylhexyl) phthalate induces cytotoxicity in HEK‐293 cell line, implication of the Nrf‐2/HO‐1 antioxidant pathway

Amara

Timoumi

Graiet

et al. 2019

Environmental Toxicology

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The di (2‐ethylhexyl) phthalate (DEHP) is a plasticizer used in the polyvinyl chloride industry. Human exposure to this plasticizer is inevitable and contributes to several side effects. In this study, we examined whether DEHP induces apoptosis and oxidative stress in embryonic kidney cells (HEK‐293) and whether the nuclear factor E2‐related factor 2 (Nrf‐2)/heme oxygenase‐1 (HO‐1) antioxidant pathway is involved in the pathogenesis of this process. We demonstrated that DEHP is cytotoxic to HEK‐293 cells. It causes oxidative damage through the generation of free radicals, induces lipid peroxidation, and alters superoxide dismutase and catalase activities. Simultaneously, DEHP treatment decreases the expression and the protein level of Nrf‐2 and HO‐1. Inhibition of the Nrf‐2/HO‐1 pathway is related to the mitochondrial pathway of apoptosis. This apoptotic process is characterized by a loss of mitochondrial transmembrane potential (ΔΨm) and upregulation of the expression of caspase‐3 mRNA as well as its protein level.

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A global assessment of phthalates burden and related links to health effects

Cited by 384 publications

References 126 publications

Epoxidized vegetable oil and bio‐based materials as PVC plasticizer

Epoxidized vegetable oil and bio‐based materials as PVC plasticizer

Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)

Di (2‐ethylhexyl) phthalate induces cytotoxicity in HEK‐293 cell line, implication of the Nrf‐2/HO‐1 antioxidant pathway

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