A global representation of vitamin D status in healthy populations

Wahl, D. A.; Cooper, Cyrus; Ebeling, Peter R.; Eggersdorfer, Manfred; Hilger, Jennifer; Hoffmann, Kristina; Josse, Robert G.; Kanis, John А.; Mithal, Ambrish; Pierroz, Dominique D.; Stenmark, J; Stöcklin, Elisabeth; Dawson‐Hughes, Bess

doi:10.1007/s11657-012-0093-0

Cited by 277 publications

(222 citation statements)

References 208 publications

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“…We found that CCM patients with one or more features of the more aggressive chronic clinical course had lower 25-(OH) vitamin D and non-HDL cholesterol values. The ROC curve generated threshold of 25.68 ng/ml for vitamin D found in the chronic aggressive group, represents a suboptimal value according to published consensus statement [29] and systematic reviews [20,30] designating 30 ng/ml as the value below which vitamin D is insufficient. This shows that CCM subjects with chronic disease aggressiveness not only have lower vitamin D levels compared with those with nonaggressive disease, but are actually deficient compared with the general population.…”

Section: Rock Activity In Leukocytes and Plasma Crp Activity Are Not Comentioning

confidence: 99%

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

et al. 2016

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Aim: To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. Patients & methods: A prospective case–control study enrolled 43 CCM patients, where 25-(OH) vitamin D, HDL and non-HDL cholesterol, CRP plasma levels and leukocyte ROCK activity were correlated with parameters of disease aggressiveness reflecting chronic and acute domains. Results: Patients with one or more features of chronically aggressive disease (early age at symptom onset, two or more symptomatic bleeds, high lesion burden) had significantly lower 25-(OH) vitamin D and non-HDL cholesterol levels in comparison to patients without these features. Conclusion: Validation of these biomarkers and their potential treatment modulation may influence the clinical care of patients with CCM disease.

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Section: Rock Activity In Leukocytes and Plasma Crp Activity Are Not Comentioning

confidence: 99%

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

et al. 2016

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“…An extensive array of studies including a mix of both representative and convenience sampling frames have reported 25(OH)D concentrations among older adults all over the globe (8,(26)(27)(28) . Without doubt, the region with the most available data on 25(OH)D concentrations is Europe, followed by North America and Asia.…”

Section: Circulating 25(oh)d Concentrations In Older Agementioning

confidence: 99%

Vitamin D and bone health outcomes in older age

2013

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The aim of this review is to summarise the evidence linking vitamin D to bone health outcomes in older adults. A plethora of scientific evidence globally suggests that large proportions of people have vitamin D deficiency and are not meeting recommended intakes. Older adults are at particular risk of the consequences of vitamin D deficiency owing to a combination of physiological and behavioural factors. Epidemiological studies show that low vitamin D status is associated with a variety of negative skeletal consequences in older adults including osteomalacia, reduced bone mineral density, impaired Ca absorption and secondary hyperparathyroidism. There seems to be inconsistent evidence for a protective role of vitamin D supplementation alone on bone mass. However, it is generally accepted that vitamin D (17 . 5 mg/ d) in combination with Ca (1200 mg/d) reduces bone loss among older white subjects. Evidence for a benefit of vitamin D supplementation alone on reducing fracture risk is varied. According to a recent Agency for Healthcare Research and Quality review in the USA the evidence base shows mixed results for a beneficial effect of vitamin D on decreasing overall fracture risk. Limitations such as poor compliance with treatment, incomplete assessment of vitamin D status and large drop-out rates however, have been highlighted within some studies. In conclusion, it is generally accepted that vitamin D in combination with Ca reduces the risk of non-vertebral fractures particularly those in institutional care. The lack of data on vitamin D and bone health outcomes in certain population groups such as diverse racial groups warrants attention. 25-hydroxyvitamin D: Vitamin D requirements: Older age: Bone mineral density: FracturesOsteoporosis is a condition characterised by a low bone mass and microarchitectural deterioration of bone with a consequent increase in bone fragility and susceptibility to fracture. In the UK, it is estimated that 3 million people are affected with osteoporosis. Furthermore, one in two British women and one in five British men aged > 50 years will experience an osteoporotic fracture in their lifetime with the estimated costs in the UK being about £1 . 7 billion annually. In the European Union, it has been estimated that previous and incident fractures accounted for 1 180 000 quality-adjusted life years lost during 2010 (1) . Furthermore, with an ageing population, the costs associated with treating osteoporosis in the EU are expected to increase by 25% in 2025(1) . Bone is a dynamic tissue that responds to the external and internal environments to which it is exposed during an individual's lifetime. While a considerable proportion (up to 70%) of the inter-individual variation in bone mass is genetically determined, lifestyle factors such as diet and exercise are well established modifiable factors of bone mass. Bone turnover is important for the self-repair of skeletal tissue (2) as well as maintaining mineral homoeostasis (e.g. Ca and P) and the balance between the rate of bone formation ...

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“…Low levels of vitamin D are reported in diverse populations around the world (1)(2)(3) , with one review suggesting that as many as 14 % of the world's population have levels inadequate for general well-being (4) . Serum concentration of 25-hydroxyvitamin D (s-25(OH)D) is the standard assessment for vitamin D status in the body and s-25(OH)D concentration of 50 nmol/l or more is considered sufficient for optimal bone-related health outcomes by the Institute of Medicine (5) .…”

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Vitamin D status in pre-school children in rural Nepal

Avagyan

Gundersen²,

Madar³

2015

Public Health Nutr.

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Objective: Vitamin D plays a major role in Ca and bone metabolism, and its extraskeletal functions are being appraised. Although inadequate vitamin D concentrations have been reported in populations worldwide, too little is known about vitamin D status and its determinants among children in developing countries. We aimed to determine vitamin D status and its determinants in Nepalese children of pre-school age. Design: A community-based, cross-sectional study. Setting: Rural Nepal at latitude 27·39°N. Subjects: Healthy children (n 280) aged 12-60 months, selected randomly from the records of a vitamin A supplementation programme. Blood samples were collected using the dried blood spot technique and analysed for serum 25-hydroxyvitamin D (s-25(OH)D) concentration using liquid chromatographytandem mass spectrometry. Ca intake and background variables were assessed with a structured questionnaire. Results: Hypovitaminosis D, defined as s-25(OH)D concentration less than 50 nmol/l, was found in 91·1 % of the children. S-25(OH)D concentration was not related to gender, socio-economic indicators, sun exposure or nutritional status. Currently breast-fed children had higher s-25(OH)D concentrations (36·4 (SD 13·2) nmol/l) than those who were not (28·6 (SD 9·8) nmol/l, P < 0·001). Adjustment for sociodemographic factors did not alter the results. Conclusion: There is widespread vitamin D deficiency among pre-school children in a rural area of Nepal. In our sample, sociodemographic factors did not affect the vitamin D status of children, but prolonged breast-feeding was associated with higher s-25(OH)D concentrations. Further research is required to investigate the health consequences of poor vitamin D status for this population. Low levels of vitamin D are reported in diverse populations around the world (1-3) , with one review suggesting that as many as 14 % of the world's population have levels inadequate for general well-being (4) . Serum concentration of 25-hydroxyvitamin D (s-25(OH)D) is the standard assessment for vitamin D status in the body and s-25(OH)D concentration of 50 nmol/l or more is considered sufficient for optimal bone-related health outcomes by the Institute of Medicine (5) . Studies from Turkey, the Middle East and India have revealed that up to 50 % of children have vitamin D deficiency (6) . A number of determinants that affect s-25(OH)D concentration in children have been identified and include skin pigmentation, prolonged breast-feeding without vitamin D supplementation and low consumption of foods rich in vitamin D (7) . However, little is known about the vitamin D status of Nepalese children.Nepal is a predominantly Hindu nation bordering Tibet and India, located between the latitudes of 26°N and 31°N. Nepalese cultural values do not restrict sun exposure and about 300 d per year are sunny (8) . A few studies that have investigated vitamin D status in special groups in Nepal, such as pregnant women and alcohol-abusing populations, report a wide range of vitamin D deficiency prevalence rat...

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A global representation of vitamin D status in healthy populations

Cited by 277 publications

References 208 publications

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

Peripheral Plasma Vitamin D and Non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease

Vitamin D and bone health outcomes in older age

Vitamin D status in pre-school children in rural Nepal

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