A global scale COVID-19 variants time-series analysis across 48 countries

Chu, Rachel Yui Ki; Szeto, Kam Chiu; Wong, Irene; Chung, Pui Hong

doi:10.3389/fpubh.2023.1085020

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Furthermore, in 2023, fewer people are seeking or being offered diagnostic testing for SARS-CoV-2 now that the virus is less virulent and endemic. [11][12][13] As a result, people who were never tested for SARS-CoV-2 infection may develop WHO PCC criteria without ever being diagnosed with SARS-CoV-2.…”

Section: Introductionmentioning

confidence: 99%

Post-COVID-19 Condition Symptoms Among Emergency Department Patients Tested for SARS-CoV-2 Infection

Archambault,

Rosychuk,

Audet

et al. 2023

Preprint

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Importance: Symptoms of Post-COVID-19 Condition (PCC) are non-specific and can occur due to other medical conditions, making it a challenge to distinguish PCC from other health conditions. Objective: To compare the proportion of emergency department (ED) patients who developed symptoms consistent with PCC between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection and time-matched patients who tested negative. Design: Observational cohort study that enrolled consecutive eligible patients between October 18, 2020, and February 28, 2022. Setting: Thirty-three Canadian COVID-19 ED Rapid Response Network sites. Participants: Eligible patients were aged ≥18 years and tested for SARS-CoV-2. We excluded patients not contacted after 5 attempts, unable to communicate due to language or cognitive barriers, deceased, or those who reported a subsequent positive test or symptomatic infection. Exposure: SARS-CoV-2 infection. Main outcome and Measure:Based on the World Health Organization (WHO) clinical case definition, our primary outcome was the proportion of ED patients reporting at least one new PCC-consistent symptom arising in the three months after the ED visit that was still present at the three-month mark and lasted >2 months. Results: Of 29,838 individuals assessed for eligibility, 6,723 were included (58% SARS-CoV-2 positive; 51% female; mean age, 54.4 years [SD: 17.9]). Among 3,933 test-positive patients, 38.9% (1532/3933, 95% CI: 37.4-40.4%) reported PCC symptoms at 3 months compared to 20.7% (578/2790, 95% CI: 19.2-22.2%) of test-negative patients. Test-positive patients reported experiencing each individual PCC-consistent symptom at least twice as often as test-negative patients. The top three most frequently reported symptoms reported by test-positive patients were post-exertional malaise, dyspnea and memory problems. The most important predictor of subsequent PCC was a positive SARS-CoV-2 test during the index ED visit (adjusted OR=4.42). Conclusions and Relevance: Over one-third of ED patients with a proven acute SARS-CoV-2 infection met PCC criteria at 3 months post-index ED visit, however one in five test-negative patients also reported PCC-consistent symptoms highlighting the lack of specificity of the WHO clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of PCC become available for diagnosis and treatment referral. Trial registration: Clinicaltrials.gov, no. NCT04702945

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Section: Introductionmentioning

confidence: 99%

Post-COVID-19 Condition Symptoms Among Emergency Department Patients Tested for SARS-CoV-2 Infection

Archambault,

Rosychuk,

Audet

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection

Archambault,

Rosychuk,

Audet

et al. 2024

Nat Commun

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Symptoms of the Post-COVID-19 Condition are often non-specific making it a challenge to distinguish them from symptoms due to other medical conditions. In this study, we compare the proportion of emergency department patients who developed symptoms consistent with the World Health Organization’s Post-COVID-19 Condition clinical case definition between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 infection and time-matched patients who tested negative. Our results show that over one-third of emergency department patients with a proven acute infection meet Post-COVID-19 Condition criteria 3 months post-index visit. However, one in five test-negative patients who claim never having been infected also report symptoms consistent with Post-COVID-19 Condition highlighting the lack of specificity of the clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of Post-COVID-19 Condition become available for diagnosis and treatment.

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A global scale COVID-19 variants time-series analysis across 48 countries

Cited by 2 publications

References 17 publications

Post-COVID-19 Condition Symptoms Among Emergency Department Patients Tested for SARS-CoV-2 Infection

Post-COVID-19 Condition Symptoms Among Emergency Department Patients Tested for SARS-CoV-2 Infection

Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection

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