A global view of pediatric urology

deVries, Catherine R.

doi:10.1016/j.jpurol.2022.02.002

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…The older age means a higher likelihood of experiencing menopause, which is associated with a decrease in estrogen stimulation and the development of genitourinary disorders such as vaginitis, bladder dysfunction, and urethral dysfunction [ 47 , 48 ]. Other potential contributing factors include tobacco use, a higher number of sexual partners, and higher fertility rates in the UK [ 29 , 46 , 48 – 51 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom

Bao,

Lu,

Wang

et al. 2023

BMC Med

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Background Multimorbidity is better prevented in younger ages than in older ages. This study aims to identify the differences in comorbidity patterns in middle-aged inpatients from China and the United Kingdom (UK). Methods We utilized 184,133 and 180,497 baseline hospitalization records in middle-aged populations (40–59 years) from Shaanxi, China, and UK Biobank. Logistic regression was used to calculate odds ratios and P values for 43,110 unique comorbidity patterns in Chinese inpatients and 21,026 unique comorbidity patterns in UK inpatients. We included the statistically significant (P values adjusted by Bonferroni correction) and common comorbidity patterns (the pattern with prevalence > 1/10,000 in each dataset) and employed network analysis to construct multimorbidity networks and compare feature differences in multimorbidity networks for Chinese and UK inpatients, respectively. We defined hub diseases as diseases having the top 10 highest number of unique comorbidity patterns in the multimorbidity network. Results We reported that 57.12% of Chinese inpatients had multimorbidity, substantially higher than 30.39% of UK inpatients. The complete multimorbidity network for Chinese inpatients consisted of 1367 comorbidities of 341 diseases and was 2.93 × more complex than that of 467 comorbidities of 215 diseases in the UK. In males, the complexity of the multimorbidity network in China was 2.69 × more than their UK counterparts, while the ratio was 2.63 × in females. Comorbidities associated with hub diseases represented 68.26% of comorbidity frequencies in the complete multimorbidity network in Chinese inpatients and 55.61% in UK inpatients. Essential hypertension, dyslipidemia, type 2 diabetes mellitus, and gastritis and duodenitis were the hub diseases in both populations. The Chinese inpatients consistently demonstrated a higher frequency of comorbidities related to circulatory and endocrine/nutritional/metabolic diseases. In the UK, aside from these comorbidities, comorbidities related to digestive and genitourinary diseases were also prevalent, particularly the latter among female inpatients. Conclusions Chinese inpatients exhibit higher multimorbidity prevalence and more complex networks compared to their UK counterparts. Multimorbidity with circulatory and endocrine/nutritional/metabolic diseases among both Chinese and UK inpatients necessitates tailored surveillance, prevention, and intervention approaches. Targeted interventions for digestive and genitourinary diseases are warranted for the UK.

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Section: Discussionmentioning

confidence: 99%

Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom

Bao,

Lu,

Wang

et al. 2023

BMC Med

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“…Although this audit is limited by sample size, insights from these findings would be useful in improving pediatric urology training. A recent article on a global view of pediatric urology[ 11 ] showed that there is a decreasing interest in subspecialization due to multiple factors. In this present survey also several trainees were reluctant to spend 2 further years for PUF training – as in the 2-year NBE program.…”

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confidence: 99%

Current Status and Scope of Pediatric Urology Fellowship Training in India

Babu

2023

Journal of Indian Association of Pediatric Surgeons

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The disparities in clinical trials addressing urologic conditions among lower-income countries

Choksi¹,

Hayden²,

Rahman³

et al. 2023

Front. Urol.

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IntroductionGenitourinary pathologies are increasingly common in low and lower-middle Q6 income countries (LMICs) however there is a disproportionate distribution of clinical trials in higher income countries as compared to LMICs. In order for evidence-based practice to be implemented in LMICs with regards to urologic conditions and malignancies, clinical trials need to be performed within LMICs such that the results can be analyzed based on the context of the local environment.MethodsWe queried ClinicalTrials.gov and the ICTRP for active clinical trials that were related to ‘prostatic neoplasms’, ‘urinary bladder neoplasms’, ‘kidney neoplasms’, ‘urolithiasis’, ‘urinary tract infections’ and ‘lower urinary tract symptoms’. The national incidence and DALYs was obtained from the Global Burden of Disease 2019 to analyze for a correlation between the numbers of clinical trials performed in a country with the burden of disease.ResultsA total of 4,169 clinical trials were identified based on the search query terms. Ninety percent of the clinical trials are being conducted in 32 countries. A majority of clinical trials are being performed in HICs. The proportion of non-oncologic urologic clinical trials performed in LMICs is greater than the proportion of urologic oncology clinical trials performed in LMICs (p <0.001). Linear regression models demonstrates a weak relationship between the global burden of disease and the number of clinical trials conducted in each country for the individual urologic conditions.DiscussionA majority of urologic clinical trials are being conducted in high-income countries which does not coincide with the global burden of disease of urologic conditions.

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A global view of pediatric urology

Cited by 4 publications

References 49 publications

Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom

Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom

Current Status and Scope of Pediatric Urology Fellowship Training in India

The disparities in clinical trials addressing urologic conditions among lower-income countries

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