A Glucose Sensor with a Plasma-Polymerized Thin Film Fabricated by Dry Processes

Hiratsuka, Atsunori; Muguruma, Hitoshi; Sasaki, Satoshi; Karube, Isao

doi:10.1002/(sici)1521-4109(199911)11:15<1098::aid-elan1098>3.0.co;2-n

Cited by 20 publications

(9 citation statements)

References 22 publications

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“…Recently, new glucose sensors of the hydrogen peroxide detection type have been developed using sinusoidal potential [326], electropolymerized bilayer films [327], a biotinylated alginate immobilization matrix [328], microfabrication techniques [329] with PPF to avoid the influences of ascorbic acid by size-discrimination [330,331], or a new method for electrogeneration of a hydrophilic crosslinked polypyrrole film for enzyme electrode fabrication [332]. Mediator-type glucose sensors were also developed using a printing technique [333] or a nitrocellulose strip for a disposable sensor electrode [334].…”

Section: Glucose Sensorsmentioning

confidence: 99%

Current research activity in biosensors

Nakamura

Karube

2003

Analytical and Bioanalytical Chemistry

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261

129

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Biosensors consist of a molecular recognition element and a transducer. Since the first biosensor was developed by Updike and Hicks many biosensors and their associated techniques have been studied and developed. In this review current research activity on the fundamentals and applications of biosensors is summarized. In discussion of the former, molecular recognition elements, techniques and tools for biosensor construction, and basic biosensor devices are introduced. Coverage of the latter includes description of biosensors for environmental, food, and clinical fields. Chemical sensors developed in our laboratory for environmental monitoring are also described. This review mainly summarizes work performed by our group and by our colleagues, and refers to the main review articles summarizing each field of biosensor research in recent years.

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Section: Glucose Sensorsmentioning

confidence: 99%

Current research activity in biosensors

Nakamura

Karube

2003

Analytical and Bioanalytical Chemistry

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261

129

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“…[3][4][5][6][7][8] Besides, using a natural polymer as a dispersant is a requirement of environment protection. Carbon nanotubes have attracted much attention because they have the ability to promote electron transfer reactions when used as electrode materials, 9,10 but carbon nanotubes are very stable and insoluble in most solvents, which restrained its application in electroanalysis.…”

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confidence: 99%

A Chitosan-Multiwall Carbon Nanotube Modified Electrode for Simultaneous Detection of Dopamine and Ascorbic Acid

et al. 2004

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Dopamine (DA) is a very important neurotransmitter in the mammalian central nervous system. Because low levels of DA have been found in patients with Parkinson's disease, 1 its detection with high selectivity and sensitivity is of great significance in investigating its physiological functions and the diagnose of nervous diseases resulting from an abnormal metabolite. When solid electrodes are used to detect DA, the main and foremost difficulty is the interference of ascorbic acid (AA), which is oxidized at almost the same potential as DA.2 It is thus very important to develop an electrochemical method of high selectivity and sensitivity for the determination of DA.Chitosan, which is derived from chitin, has excellent biologic compatibility and can be used as a modifier because it has many amino and hydroxyl groups.3-8 Besides, using a natural polymer as a dispersant is a requirement of environment protection. Carbon nanotubes have attracted much attention because they have the ability to promote electron transfer reactions when used as electrode materials, 9,10 but carbon nanotubes are very stable and insoluble in most solvents, which restrained its application in electroanalysis. Thus, in this study, a multiwall carbon nanotube (MWNT)-chitosan modifier was obtained by putting MWNT into a chitosan solution (0.5%). The MWNTchitosan modified electrode (MC/GCE) has many advantages with regard to a low detection limit, a fast response, excellent reproducibility for the detection for DA and AA simultaneously. Experimental ApparatusAll of the electrochemical measurements were carried out with a bioanalytical system CV-50W electrochemical analyzer. The three-electrode system consisted of a modified GCE, a saturated calomel reference electrode (SCE), and a platinum auxiliary electrode. All potentials were referred to the SCE. The transmission electron microscopy image was done with a TEM-100CXII. ReagentsDopamine, ascorbic acid (Fluka Corp.). A chitosan solution (0.5%) was prepared by dissolving 0.05 g of chitosan in 10 ml acetic acid (2 mol l -1 ). 11 The MWNT used in this work (obtained from the Institute of Nanometer, Central China Normal University) was synthesized by catalytic pyrolysis and purified followed the method given in a reference. 12 Preparation for a MWNT-chitosan modified electrodeUpon putting 1 mg of MWNT into 5 mL of a chitosan solution (0.5%), ultrasonic agitation for a few minutes gave 0.2 mg ml -1 of a black suspension. Before being modified, the GCE was polished with 0.3 µm and 0.05 µm aluminum slurry, rinsed thoroughly with redistilled water, then ultrasonically rinsed with alcohol, redistilled water for 1 min each, and dried under an infrared lamp. After the GCE was cooled, it was smeared evenly with 10 µl of a MWNT-chitosan (0.5%) solution by a micro-syringe, and then dried under an infrared lamp for 10 min. After cooling, the MC/GCE could be used. Experimental procedureA 0.1 mol l -1 phosphate buffer solution (pH = 7.2) was used as the supporting electrolyte for the determination of DA and AA...

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“…The calibration plots of the sensor were linear, from 0.05 mmol=L glucose to 2 mmol=L, and the variance for a series of 10 injections of 2 mmol=L glucose was found to be 2 %. Another sensor using plasma-polymerized ®lms was reported [55]. This sensor overcomes the poor adhesion on slide glass or silicon substrates without the chromium layer that is often used between the glass slide and platinum to promote adhesion but causes undesirable electrochemical side reactions with an alloy formation of platinum and chromium.…”

Section: Catalytic Biosensorsmentioning

confidence: 99%

Plasma Polymerized Films for Sensor Devices

Hiratsuka

Karube

2000

Electroanalysis

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Miniaturization with semiconductor microfabrication or micromachining techniques is one of the main concerns in sensor technologies. For the combination of sensor and microelectronics technology, polymers should be fabricated in a mass‐producible and miniaturization‐conscious manner as an interface. The polymers fabricated in conventional manners could have potential problems, e.g., obtaining thin (<1 µm) and homogeneous films. Plasma‐polymerized films, which are made in a glow discharge or plasma in a vapor phase, offer a new alternative. This review describes the several characteristics, properties, and applications of plasma‐polymerized films in both chemical and biological fields.

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A Glucose Sensor with a Plasma-Polymerized Thin Film Fabricated by Dry Processes

Cited by 20 publications

References 22 publications

Current research activity in biosensors

Current research activity in biosensors

A Chitosan-Multiwall Carbon Nanotube Modified Electrode for Simultaneous Detection of Dopamine and Ascorbic Acid

Plasma Polymerized Films for Sensor Devices

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