A glutathione-activated carrier-free nanodrug of triptolide as a trackable drug delivery system for monitoring and improving tumor therapy

Abstract

Triptolide (TP) has been one of the most common systemic treatments for inflammatory and immune deseases in China for centuries. However, TP exhibits some disadvantages, such as poor solubility in...

Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

“…One study reported the development of a self-assembled glutathione-activated triptolide nanoparticle (CyssTPN), which is carrier-free. In comparison to carrier-based triptolide delivery systems, CyssTPN significantly reduced toxicity and achieved increased drug release under glutathione stimulation in tumor tissues, thereby enhancing the therapeutic efficacy [ 106 ]. In summary, these nanotechnological advancements hold great promise for enhancing the therapeutic efficacy of celastrol and triptolide while simultaneously mitigating their toxicity.…”

Gold(i) N-heterocyclic carbene complexes with tunable electronic properties for sensitive colorimetric detection of glutathione

“…1 Alterations in GSH levels are directly associated with many pathologies, including Parkinson's disease, liver damage, cancer, cardiovascular disease, and other diseases. 2,3 Owing to the biological and clinical importance of GSH, developing more susceptible, reliable, and quantitative methods to determine GSH concentrations is thus of great importance. 4…”

“…1 Alterations in GSH levels are directly associated with many pathologies, including Parkinson's disease, liver damage, cancer, cardiovascular disease, and other diseases. 2,3 Owing to the biological and clinical importance of GSH, developing more susceptible, reliable, and quantitative methods to determine GSH concentrations is thus of great importance. 4 Various analytical techniques have recently been developed for detecting GSH, including iodimetry, high-performance liquid chromatography, capillary electrophoresis, mass spectrometry, fluorescence, colorimetric methods, etc.…”

An activatable, carrier-free, triple-combination nanomedicine for ALK/EGFR-mutant non-small cell lung cancer highly permeable targeted chemotherapy

“…19,20 A promising alternative would be to develop a carrier-free, self-assembled, prodrug delivery platform with high drug permeability and synergistic efficacy in the absence of toxic excipients. [21][22][23][24][25][26][27][28][29][30] To our knowledge, stimulusresponsive and carrier-free triple-combination nano drugs based on ALK/EGFR-mutant inhibitors for highly permeable lung cancertargeted chemotherapy have rarely been reported.…”