A glycolipid adjuvant, 7DW8-5, provides a protective effect against colonic inflammation in mice by the recruitment of CD1d-restricted natural killer T cells

Lee, Chansu; Hong, Sung Noh; Kim, Young‐Ho

doi:10.5217/ir.2019.00132

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…This result prompted us to determine whether fucoidan exerts an inhibitory effect on the generation and progression of mice colitis. The treatment process for mice is shown in Figure A, in which we also referred to previous modeling approaches and the concentration of DSS used. , A significant decrease in body weight and the presence of diarrhea and bloody stools in mice were detected when 4% DSS drinking water was used (Figure B,C,E). We scored the mice with DAI for weight loss, diarrhea, and feces containing blood.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

Xin

Zheng

et al. 2022

J. Agric. Food Chem.

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Fucoidan has many biological activities, including the inhibitory effect on the development of various cancer types. This study showed that lipopolysaccharide-induced inflammation in FHC cells (normal human colonic epithelial cells) could be reversed using fucoidan at different concentrations. The fucoidan-induced anti-inflammatory effect was also confirmed through in vivo experiments in mice. Compared to the mice of the model group, the ratio of Firmicutes/Bacteroidetes in feces increased and the diversity of gut microbial composition was restored in mice after fucoidan intervention. In colorectal cancer (CRC) cells DLD-1 and SW480, fucoidan inhibited cell proliferation and promoted cell apoptosis. It also blocked the cell cycle of DLD-1 and SW480 at the G0/G1 phase. The animal model of inflammation-related CRC showed that the incidence of tumors in mice was significantly reduced by fucoidan intervention. Furthermore, the administration of fucoidan decreased the expression levels of inflammatory factors such as TNF-α IL-6 and IL-1β in the colonic tissues. Therefore, fucoidan can effectively prevent the development of colitis-associated CRC.

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Section: Resultsmentioning

confidence: 99%

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

Xin

Zheng

et al. 2022

J. Agric. Food Chem.

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“…In this work, we show that the CD1d- i NKT cell-dependent effect of 7DW8-5 44 , 50 prevents infection by SARS-CoV-2, respiratory syncytial virus (RSV), and influenza virus in animal models.…”

Section: Introductionmentioning

confidence: 82%

An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo

et al. 2023

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Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but emergence of viral variants that are antigenically distinct from the vaccine strains are of concern and additional, broadly acting preventive approaches are desirable. Here, we report on a glycolipid termed 7DW8-5 that exploits the host innate immune system to enable rapid control of viral infections in vivo. This glycolipid binds to CD1d on antigen-presenting cells and thereby stimulates NKT cells to release a cascade of cytokines and chemokines. The intranasal administration of 7DW8-5 prior to virus exposure significantly blocked infection by three different authentic variants of SARS-CoV-2, as well as by respiratory syncytial virus and influenza virus, in mice or hamsters. We also found that this protective antiviral effect is both host-directed and mechanism-specific, requiring both the CD1d molecule and interferon-$$\gamma$$ γ . A chemical compound like 7DW8-5 that is easy to administer and cheap to manufacture may be useful not only in slowing the spread of COVID-19 but also in responding to future pandemics long before vaccines or drugs are developed.

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“…Repeated intraperitoneal (i.p.) injection of either α-GalCer or its more potent analog (7DW8-5) ( 33 , 34 ) into DSS-treated mice effectively prevents colitis development. Moreover, repeated i.p.…”

Section: Effect Of Glycolipid-stimulated Inkt Cells On Ibdmentioning

confidence: 99%

Role of CD1d and iNKT cells in regulating intestinal inflammation

Lee,

Park,

Van Kaer

et al. 2024

Front. Immunol.

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Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity. By engaging with CD1d-expressing non-immune cells (such as intestinal epithelial cells and enterochromaffin cells) and immune cells (such as type 3 innate lymphoid cells, B cells, monocytes and macrophages), iNKT cells contribute to the maintenance of immune homeostasis in the intestine. In this review, we discuss the impact of iNKT cells and CD1d in the regulation of intestinal inflammation, examining both cellular and molecular factors with the potential to influence the functions of iNKT cells in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.

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A glycolipid adjuvant, 7DW8-5, provides a protective effect against colonic inflammation in mice by the recruitment of CD1d-restricted natural killer T cells

Cited by 4 publications

References 26 publications

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo

Role of CD1d and iNKT cells in regulating intestinal inflammation

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