A Glycotherapeutic Approach to Functionalize Biomaterials‐Based Systems

Abstract

In addition to being one of the primary building block materials of living cells, glycans are also favorable candidates for therapeutic applications. In the mid-20th century, the progress of glycans in the drug discovery field became surpassed by protein and DNA-focused treatments. However, the emergence of new analytical tools and methods to synthesize structurally specific glycans has encouraged and motivated the scientific community toward the development of glycan-based therapeutics. This review discusses the reemergence of glycan-based agents in the last decade and the technical strategies that played a key role in bringing the glycanbased treatments into the limelight of modern medicine. The review also includes the application of native glycans as the therapeutic agents along with the chemically engineered cell surface glycans and proteins to meet the preclinical and clinical scenario. Glycan-based therapeutic materials hold a huge potential that can be harnessed to meet the clinical needs in medicine.

Molecularly Imprinted Polymer Hydrogel Nanoparticles: Synthetic Antibodies for Cancer Diagnosis and Therapy

“…It is abundant on the surface of cells and is part of the glycocalyx. [51] Consisting of repeated units of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (Figure 3), HA is an important component of skin (accounting for 50 % of the total body hyaluronan), cartilage, connective tissues, synovial fluid and the vitreous of the eye. [52] However, HA also plays a bioactive role during carcinogenesis and is closely correlated with tumor cell growth, proliferation and metastasis.…”

Cyclodextrin-Based Functional Glyconanomaterials

“…GlycoCDplexes formed upon nucleic acid templation of pGaCDs shall expose multiple copies of the saccharide motif at the periphery. In other words, they will bear intrinsic multivalency, an important requisite for the recognition of functional glyconano(bio)materials by cognate lectins [ 161 , 162 , 163 ]. In principle, the ligand surface density will increase with the pGaCD valency, which would be expected to translate into enhanced lectin binding avidities.…”

Iminodiacetic acid (IDA)-generated mesoporous nanopolymer: a template to relate surface area, hydrophilicity, and glycopeptides enrichment

“…Popular enrichment methodologies developed in glycoproteomics include lectin affinity chromatography (LAC) [3], hydrazide chemistry (HC) [4], boronic acid-based affinity chromatography [5], and hydrophilic interaction liquid chromatography (HILIC) [6]. HILIC is simple, reproducible, selective [7], and compatible with MS [8].…”