A gold nanocage–CNT hybrid for targeted imaging and photothermal destruction of cancer cells

Khan, Sadia Afrin; Kanchanapally, Rajashekhar; Fan, Zhen; Beqa, Lule; Singh, Anant Kumar; Senapati, Dulal; Ray, Paresh Chandra

doi:10.1039/c2cc32313c

Cited by 68 publications

(65 citation statements)

References 24 publications

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“…7 The development of novel gold nanostructures and hybrids with a more efficient light-to-heat conversion is the other option. 27,28,30 The wrapping and embedding of gold nanostructures within graphene oxide (GO) and reduced graphene oxide (rGO) could be a way into this direction. [31][32][33] Kohane and coworkers showed that rGO coated gold nanoparticles kill cells more rapidly under 808 nm irradiation with a laser intensity of 3 W cm −2 , than did uncoated particles.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

et al. 2016

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“…197 In photo-triggered thermal activated drug release, low power densities e.g. 0.20 W cm −2 (Ag–Au shell–core), 160 0.6 W cm −2 (reduced GO), 198 and 1–2 W cm −2 (gold nanocage–CNT hybrid) 199 have been reported that do not damage tissue. Photo-triggered thermal systems have also led to a type of photochemotherapy with advantages including on-demand drug release, destruction of tumor cells either in light treated or light-shielded areas (the latter one due to heat-generated diffusing in the tissue), with a light-dosage dependent response.…”

Section: Different Stimuli-responsive Mnpsmentioning

confidence: 99%

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

et al. 2016

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New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various differences between the extracellular and intracellular environments of cancerous and normal cells and the particular characteristics of tumors such as physicochemical properties, neovasculature, elasticity, surface electrical charge, and pH have motivated the design and fabrication of inventive “smart” MNPs for stimulus-responsive controlled drug release. These novel MNPs can be tailored to be responsive to pH variations, redox potential, enzymatic activation, thermal gradients, magnetic fields, light, and ultrasound (US), or can even be responsive to dual or multi-combinations of different stimuli. This unparalleled capability has increased their importance as site-specific controlled drug delivery systems (DDSs) and has encouraged their rapid development in recent years. An in-depth understanding of the underlying mechanisms of these DDS approaches is expected to further contribute to this groundbreaking field of nanomedicine. Smart nanocarriers in the form of MNPs that can be triggered by internal or external stimulus are summarized and discussed in the present review, including pH-sensitive peptides and polymers, redox-responsive micelles and nanogels, thermo- or magnetic-responsive nanoparticles (NPs), mechanical- or electrical-responsive MNPs, light or ultrasound-sensitive particles, and multi-responsive MNPs including dual stimuli-sensitive nanosheets of graphene. This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.

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“…SiO 2 @Au NPs were applied to optical imaging [229], biomedical detection [230], and photothermal cancer therapeutic ability [231], and may enable a new class of infrared materials, components, and devices to be developed. AuNCs and Au nanoframes were investigated in catalysis [232] and biosensing in view of their controllable LSPR properties that depend on the size and, most importantly, the thickness of the walls [233].…”

Section: Sensors and Molecular Recognitionmentioning

confidence: 99%

Anisotropic Gold Nanoparticles: Preparation, Properties, and Applications

Xue

2015

Anisotropic Nanomaterials

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Anisotropic metal nanoparticles with a catalog of promising anisotropic electronic, optical, and chemical properties have been regarded as enabling building blocks in the bottom-up fabrication of functional materials and devices. Specifically, anisotropic gold nanoparticles are currently emerging as fascinating materials due to their unique shape-, size-, and surface-dependent properties. In this chapter, we present the synthesis, properties and applications of different one-, twoand three-dimensional anisotropic gold nanoparticles (AuNPs). The most widely adopted top-down and bottom-up synthesis approaches have been discussed in addition to some of the recently introduced new methods for the fabrication of differently shaped anisotropic AuNPs. The optical property, photothermal effect, surface enhanced Raman scattering, fluorescence enhancement and quenching, surface modification, toxicology, and supramolecular organizations of anisotropic AuNPs have been highlighted. Various practical and potential applications of anisotropic AuNPs in catalysis, sensing, photothermal therapy, drug and gene delivery, and biological and biomedical areas are briefly outlined.

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A gold nanocage–CNT hybrid for targeted imaging and photothermal destruction of cancer cells

Abstract: This communication reports the design of a novel aptamer conjugated gold nanocage decorated SWCNTs hybrid nanomaterial for targeted imaging and selective photothermal destruction of the prostate cancer cells.

Cited by 68 publications

References 24 publications

Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

Plasmonic photothermal cancer therapy with gold nanorods/reduced graphene oxide core/shell nanocomposites

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Anisotropic Gold Nanoparticles: Preparation, Properties, and Applications

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