A Golgi study on the dorsal nucleus of the lateral lemniscus in the mouse

Iwahori, Nobuharu

doi:10.1016/0168-0102(86)90002-7

Cited by 31 publications

(22 citation statements)

References 27 publications

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“…This is unlikely for several reasons. The first reason follows from the observations by Iwahori (1986). From Golgi-impregnated material in the rat, he observed that most ascending fibers provide collateral innervation to the DNLL.…”

Section: Discussionmentioning

confidence: 91%

“…Heterogeneity among the population of DNLL neurons is also indicated by anatomical studies. Several investigators report that the DNLL in the cat and rat is composed of several types of neurons and that each type is localized to a particular DNLL region (Kane and Barone, 1980;Iwahori, 1986;Shneiderman et al, 1988;Bajo et al, 1993). The significance of the various cell types, however, is unclear.…”

Section: Indexing Terms: Amplitude Modulation Temporal Discharge Patmentioning

confidence: 97%

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Afferent connections to the dorsal nucleus of the lateral lemniscus of the mustache bat: evidence for two functional subdivisions

Yang¹,

Liu²,

Pollak³

1996

J. Comp. Neurol.

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The dorsal nucleus of the lateral lemniscus (DNLL) of the mustache bat, Pteronotus parnellii, was found to consist of two divisions. The neurons in each division were distinguished by their temporal discharge patterns evoked both by tone bursts and sinusoidal amplitude-modulated (SAM) signals. Neurons in the anterior one-third of the DNLL responded to tone bursts with an onset discharge pattern and only phase-locked to SAM signals with low modulation frequencies (< 300 Hz). Neurons in the posterior two-thirds of the DNLL responded to tone bursts with a sustained discharge pattern and phase-locked to SAM signals with much higher modulation frequencies (400-800 Hz). In addition, there was a different frequency representation in the two divisions. The frequency representation in the posterior division was from about 15 to 120 kHz, whereas in the anterior division it was only up to 62 kHz. The physiological differences were further supported by data from experiments that revealed the sources of afferent projections to the two DNLL divisions. Retrograde labeling showed that the afferent projections to the two divisions were from different neuronal populations. Input differences were of two types. Some nuclei projected to one or the other DNLL division, but not to both. For instance, the ventral nucleus of the lateral lemniscus projected predominately to the anterior DNLL and provided little or no inputs to the posterior DNLL, whereas the medial superior olive innervated the posterior but not the anterior DNLL. Other lower nuclei projected to both DNLL divisions. These include the contralateral cochlear nucleus, the ipsi- and contralateral lateral superior olives, the intermediate nucleus of the lateral lemniscus, and the contralateral DNLL. However, the projections to each division of the DNLL originate from different neuronal subpopulations in each lower nucleus. The functional implications of these findings are discussed in the context of the possible impacts that the two DNLL divisions exert on their postsynaptic targets in the inferior colliculus.

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Section: Discussionmentioning

confidence: 91%

Section: Indexing Terms: Amplitude Modulation Temporal Discharge Patmentioning

confidence: 97%

Afferent connections to the dorsal nucleus of the lateral lemniscus of the mustache bat: evidence for two functional subdivisions

Yang¹,

Liu²,

Pollak³

1996

J. Comp. Neurol.

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“…So far, the number of contact sites required to harbor this quantal content are not known. Anatomical evidence, however, suggests that the size of synaptic boutons originating from ascending SOC fibers is large and several contacts are made onto a given neuron by a single fiber (Iwahori, 1986;Henkel, 1997). Fibers of the medial superior olive (MSO) were shown to make up to four large contacts onto a single DNLL neuron (Henkel, 1997).…”

Section: Implications Of the Basic Cellular And Synaptic Propertiesmentioning

confidence: 99%

“…Indeed, from the maximal evoked currents, it is indicated that at least 10 excitatory fibers converge onto a DNLL neuron. Thus, AP generation in the DNLL is based on a substantial convergence of excitatory inputs, originating in the lateral superior olive and MSO (Iwahori, 1986 difference between the minimal number of fibers required for triggering an AP in vitro and the overall convergence estimated in our slice preparation might be important for the physiological function of the DNLL circuit. First, during ongoing activity, this difference has to compensate for the synaptic depression that leads to a reduced charge per afferent fiber.…”

Section: Implications Of the Basic Cellular And Synaptic Propertiesmentioning

confidence: 99%

“…Excitation to the DNLL network is mainly supplied by ascending fibers originating from the superior olivary complex (SOC) (Glendenning et al, 1981;Iwahori, 1986;Shneiderman et al, 1988;Oliver and Shneiderman, 1989;Huffman and Covey, 1995;Henkel, 1997;Siveke et al, 2006). The GABAergic output of the DNLL projects to its contralateral counterpart and both hemispheres of the inferior colliculus (Shneiderman et al, 1988;Kelly et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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NMDA Currents Modulate the Synaptic Input–Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils

Porres

Meyer²,

Grothe³

et al. 2011

J. Neurosci.

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Neurons in the dorsal nucleus of the lateral lemniscus (DNLL) receive excitatory and inhibitory inputs from the superior olivary complex (SOC) and convey GABAergic inhibition to the contralateral DNLL and the inferior colliculi. Unlike the fast glycinergic inhibition in the SOC, this GABAergic inhibition outlasts auditory stimulation by tens of milliseconds. Two mechanisms have been postulated to explain this persistent inhibition. One, an "integration-based" mechanism, suggests that postsynaptic excitatory integration in DNLL neurons generates prolonged activity, and the other favors the synaptic time course of the DNLL output itself. The feasibility of the integrationbased mechanism was tested in vitro in DNLL neurons of Mongolian gerbils by quantifying the cellular excitability and synaptic inputoutput functions (IO-Fs). All neurons were sustained firing and generated a near monotonic IO-F on current injections. From synaptic stimulations, we estimate that activation of approximately five fibers, each on average liberating ϳ18 vesicles, is sufficient to trigger a single postsynaptic action potential. A strong single pulse of afferent fiber stimulation triggered multiple postsynaptic action potentials. The steepness of the synaptic IO-F was dependent on the synaptic NMDA component. The synaptic NMDA receptor current defines the slope of the synaptic IO-F by enhancing the temporal and spatial EPSP summation. Blocking this NMDA-dependent amplification during postsynaptic integration of train stimulations resulted into a ϳ20% reduction of the decay time course of the GABAergic inhibition. Thus, our data show that the NMDA-dependent amplification of the postsynaptic activity contributes to the GABAergic persistent inhibition generated by DNLL neurons.

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Axonal morphology in fibrodendritic laminae of the dorsal nucleus of the lateral lemniscus: Afferent projections from the medial superior olivary nucleus

Henkel

1997

J. Comp. Neurol.

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The distribution and morphology of axons projecting from the medial superior olivary nucleus to the dorsal nucleus of the lateral lemniscus were studied in the adult cat. Injections of Phaseolus vulgaris-leucoagglutinin, biocytin, or dextran-rhodamine in the medial superior olivary nucleus labeled axons that ascended in the lateral lemniscus. Before entering the inferior colliculus, collateral branches of these labeled axons ended in the dorsal nucleus of the lateral lemniscus in thin, horizontal bands forming laminae that extended throughout the rostral-caudal length of the dorsal nucleus of the lateral lemniscus. A dorsal-ventral topography was apparent in the position of the lamina with respect to the injection site, but no relation between the rostral-caudal location of labeled endings and the injection site was observed. There was a divergent pattern of connections within the horizontal laminae rather than a point-to-point organization. The terminal branches of the collateral axons exhibited round or oval boutons en passant and terminaux. Individual arbors reconstructed from serial sections distributed varicosities in circumscribed domains that were only a subcomponent of the area of the afferent laminae in which they were distributed. The spatial relationships of axonal domains of several axons labeled from a single injection in the medial superior olivary nucleus suggest a mosaic pattern in the laminar connections with the dorsal nucleus of the lateral lemniscus.

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A Golgi study on the dorsal nucleus of the lateral lemniscus in the mouse

Cited by 31 publications

References 27 publications

Afferent connections to the dorsal nucleus of the lateral lemniscus of the mustache bat: evidence for two functional subdivisions

Afferent connections to the dorsal nucleus of the lateral lemniscus of the mustache bat: evidence for two functional subdivisions

NMDA Currents Modulate the Synaptic Input–Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils

Axonal morphology in fibrodendritic laminae of the dorsal nucleus of the lateral lemniscus: Afferent projections from the medial superior olivary nucleus

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