We consider designing a robust structured sparse sensing matrix consisting of a sparse matrix with a few nonzero entries per row and a dense base matrix for capturing signals efficiently. We design the robust structured sparse sensing matrix through minimizing the distance between the Gram matrix of the equivalent dictionary and the target Gram of matrix holding small mutual coherence. Moreover, a regularization is added to enforce the robustness of the optimized structured sparse sensing matrix to the sparse representation error (SRE) of signals of interests. An alternating minimization algorithm with global sequence convergence is proposed for solving the corresponding optimization problem. Numerical experiments on synthetic data and natural images show that the obtained structured sensing matrix results in a higher signal reconstruction than a random dense sensing matrix. (Zhihui Zhu), qiuli@mines.edu (Qiuwei Li) 1 Throughout this paper, MATLAB notations are adopted: Q(m, : ), Q(:, k) and Q(i, j) denote the mth row, kth column, and (i, j)th entry of the matrix Q; q(n) denotes the nth entry of the vector q. · 0 is used to count the number of nonzero elements.