A Grading System for Lymphocytic Plasmacytic Colitis in Dogs

Abstract

Colonic mucosal samples were obtained every 4 weeks for 13 months from 6 clinically normal dogs and from 47 dogs with a clinical diagnosis of chronic inflammatory bowel disease. All samples were graded on a scale of 0-5, based upon the quantity of lymphocytes and plasma cells in the lamina propria, epithelial changes, and the presence of ulcers and erosions. A grade of less than or equal to 2.0 was considered normal and was assigned to 77 of 78 samples from clinically normal dogs and 28 of 48 samples from dogs with diarrhea. A transient increase in cellularity was noted in 1 sample from 1 control dog. Nineteen dogs with clinical disease had obvious histologic abnormalities. The grading scheme described provides the pathologist with an objective criterion for the microscopic evaluation of colonic mucosal samples obtained by endoscopic techniques and offers clinicians a method of assessing the dog's progress and response to therapy.

Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats

“…We did not attempt to determine the uniformity or accuracy of pathologists in diagnosing inflammatory bowel disease, because presently it is not clear what constitutes the gold standard for the histologic diagnosis of inflammatory bowel disease; various criteria have been proposed. [13][14][15][16][17][18] Instead, we attempted to determine whether there was uniformity or nonuniformity in the way in which different pathologists used the terms normal, mild, moderate, severe, and neoplastic to describe intestinal mucosal cellular infiltrates, because these terms are commonly used by pathologists when describing histopathologic changes in intestinal tissue specimens. 13,19 For the study to have maximum clinical applicability, we did not make any suggestions to the pathologists regarding what these terms should mean.…”

Fecal α1‐Proteinase Inhibitor Concentration in Dogs with Chronic Gastrointestinal Disease

“…Gastroduodenoscopy was performed in all dogs in group 2, and multiple pinch biopsy specimens of gastric and duodenal mucosa were collected for histologic assessment of hematoxylin‐and eosin‐stained sections in the Comparative Pathology Laboratory, University of Bristol. The IBD was graded as mild, moderate, or severe on the basis of degree of infiltration of the gastrointestinal mucosa with inflammatory cells 11–13 . Albumin concentration, measured only in dogs in group 2, was determined using the bromocresol green method on a Kone analyzer (Kone Specific, Kone Instruments, Espoo, Finland).…”

Adherent and InvasiveEscherichia coliIs Associated with Granulomatous Colitis in Boxer Dogs

“…In the non-GCB group, colitis was predominantly lymphoplasmacytic (26/27 dogs; 1 Irish Setter had eosinophilic colitis), and nonulcerative (24/27 dogs), with PASpositive macrophages absent or rarely detected. The severity of colitis in the non-GCB group, determined by the presence of ulcers or erosions, architectural changes such as glandular atrophy or dysplasia, alterations in goblet cells, and increases in cellularity, ranged from severe (n ϭ 2) through moderate (n ϭ 13) to mild (n ϭ 12) (67). Aphthous ulcers were observed in two dogs with mild colitis (one rough Collie, one German Shepherd Dog).…”