A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

Sanad, Mohamed Fathi; Shalan, Ahmed Esmail; Bazid, Shereen Magdy; Serea, Esraa Samy Abu; Hashem, Elhussein M.; Nabih, Shimaa

doi:10.1039/c9ra05669f

Cited by 43 publications

(24 citation statements)

References 56 publications

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“…Nanobiotechnology as a branch of nanoscience can use several nano-based systems for a diversity of biomedical applications, including treatment pathways of human cancers [ 1 , 2 , 3 , 4 , 5 ]. Furthermore, the reason for using nanoparticles for disease therapy depends on their structure and dimension compared to the conventional small-molecule medicines [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

Gudikandula

Srileka

Charya

et al. 2021

Heliyon

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Silver nanoparticles (AgNPs) were successfully synthesized using silver nitrate via the biological route using the culture filtrate of Ganoderma enigmaticum as well as Trametes ljubarskyi white rot fungi materials at room temperature. The proposed synthetic technique was applied for the first time for AgNPs preparation via the biological route through a low-cost pathway, which considered as an adequate direction of preparation compared to the commercial methods. This study reports the in vitro cytotoxic effect of biologically synthesized AgNPs in disposing of the human lung cancer cell line (A549) and human breast cancer cell (MCF-7) by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. In addition, the viability of the tested cell lines was tested after treatment for 24 h in the presence of the prepared nanoparticles. The obtained results indicated the reduced viability of cancer cell lines with improving concentrations of AgNPs (40–120 μg/mL) at 24 h. Furthermore, at 120 μg/mL concentration, the fungal nanoparticles showed substantial cytotoxic effects toward the treated cells. Consequently, the results designated that the biologically synthesized silver nanoparticles have effective behavior for treating A549 and MCF-7 cancer cells from the laboratory experiment approach; however, additional studies are required to validate these results in vivo models as anticancer agents depending on their cytotoxic activity.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

Gudikandula

Srileka

Charya

et al. 2021

Heliyon

Self Cite

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“…Among these, combination of rGO with gold (Au) nanoparticle has gained considerable attention. In one study, Sanad et al prepared rGO–gold nanocomposites (rGO-Au) by incorporating Au nanoparticles inside the rGO matrix through in situ reduction with sodium borohydride, followed by loading 5-FU by pore capping [ 73 ]. The results obtained from cytotoxicity assay determined by the reduced half maximal inhibitory concentration (IC 50 ) using MTT assay in addition to enhanced cell apoptosis from flow cytometry analysis suggested the nanocomposite can enhance targeted delivery of 5-FU as well as cytotoxicity to MCF-7 breast cancer cells.…”

Section: Application Of Reduced Graphene Oxide (Rgo) In Cancer Thementioning

confidence: 99%

Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy

Dash

Jose

et al. 2021

IJMS

101

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Cancer is one of the deadliest diseases in human history with extremely poor prognosis. Although many traditional therapeutic modalities—such as surgery, chemotherapy, and radiation therapy—have proved to be successful in inhibiting the growth of tumor cells, their side effects may vastly limited the actual benefits and patient acceptance. In this context, a nanomedicine approach for cancer therapy using functionalized nanomaterial has been gaining ground recently. Considering the ability to carry various anticancer drugs and to act as a photothermal agent, the use of carbon-based nanomaterials for cancer therapy has advanced rapidly. Within those nanomaterials, reduced graphene oxide (rGO), a graphene family 2D carbon nanomaterial, emerged as a good candidate for cancer photothermal therapy due to its excellent photothermal conversion in the near infrared range, large specific surface area for drug loading, as well as functional groups for functionalization with molecules such as photosensitizers, siRNA, ligands, etc. By unique design, multifunctional nanosystems could be designed based on rGO, which are endowed with promising temperature/pH-dependent drug/gene delivery abilities for multimodal cancer therapy. This could be further augmented by additional advantages offered by functionalized rGO, such as high biocompatibility, targeted delivery, and enhanced photothermal effects. Herewith, we first provide an overview of the most effective reducing agents for rGO synthesis via chemical reduction. This was followed by in-depth review of application of functionalized rGO in different cancer treatment modalities such as chemotherapy, photothermal therapy and/or photodynamic therapy, gene therapy, chemotherapy/phototherapy, and photothermal/immunotherapy.

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“…The enhanced apoptotic action is due to the generation of ROS and antioxidant action. The nanocomposite allows easy penetration of the drug into tumor cells, providing the way for 5FU action [90]. A sustained drug delivery carrier was developed by ingraining ZnO NPs in histidine conjugated chitosan hydrogel, cross-linked with dialdehyde cellulose.…”

Section: Drug and Gene Deliverymentioning

confidence: 99%

Advances of Non-Iron Metal Nanoparticles in Biomedicine

Nair¹,

Morsy²,

Shinu³

et al. 2021

J Pharm Pharm Sci

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Metal nanoparticles (MNPs) comprise of nanoparticles originating from metallic elements with additional properties inherent to metal ions. MNPs found applications in various field such as electronics, optics, mechanics, physics etc. There are many reviews on iron MNPs for biomedical application. Hence, in this review, we focus on non-iron MNPs and their vivid biomedical applications. Here, we review the applications of non-iron MNPs in biomedicine such as drug delivery, gene delivery, anticancer activity, antimicrobial activity, tissue engineering, bioimaging, and photodynamic, and photothermal therapies.

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A graphene gold nanocomposite-based 5-FU drug and the enhancement of the MCF-7 cell line treatment

Abstract: Graphene–gold nanocomposite materials combined with (5-fluorouracil, 5-FU) drug show high potent cytotoxicity against MCF-7 cells, can decrease HER-2 gene expression and cause cell cycle arrest.

Cited by 43 publications

References 56 publications

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

RETRACTED: Biogenic synthesis and cytotoxic effects of silver nanoparticles mediated by white rot fungi

Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy

Advances of Non-Iron Metal Nanoparticles in Biomedicine

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