Quantum metrology utilizes nonclassical resources, such as entanglement or squeezed light, to realize sensors whose performance exceeds that afforded by classical-state systems. Environmental loss and noise, however, easily destroy nonclassical resources and, thus, nullify the performance advantages of most quantum-enhanced sensors. Quantum illumination (QI) is different. It is a robust entanglement-enhanced sensing scheme whose 6 dB performance advantage over a coherent-state sensor of the same average transmitted photon number survives the initial entanglement's eradication by loss and noise. Unfortunately, an implementation of the optimum quantum receiver that would reap QI's full performance advantage has remained elusive, owing to its having to deal with a huge number of very noisy optical modes. We show how sum-frequency generation (SFG) can be fruitfully applied to optimum multimode Gaussian-mixedstate discrimination. Applied to QI, our analysis and numerical evaluations demonstrate that our SFG receiver saturates QI's quantum Chernoff bound. Moreover, augmenting our SFG receiver with a feedforward (FF) mechanism pushes its performance to the Helstrom bound in the limit of low signal brightness. The FF-SFG receiver, thus, opens the door to optimum quantum-enhanced imaging, radar detection, state and channel tomography, and communication in practical Gaussian-state situations. DOI: 10.1103/PhysRevLett.118.040801 Introduction.-Entanglement is essential for deviceindependent quantum cryptography [1], quantum computing [2], and quantum-enhanced metrology [3]. It has also been employed in frequency and phase estimation to beat their standard quantum limits on measurement precision [4][5][6][7][8][9][10]. Furthermore, entanglement has applications across diverse research areas, including dynamic biological measurement [11], delicate material probing [12], gravitational wave detection [13], and quantum lithography [14]. Entanglement, however, is fragile; it is easily destroyed by quantum decoherence arising from environmental loss and noise. Consequently, the entanglement-enabled performance advantages of most quantum-enhanced sensing schemes quickly dissipate with increasing quantum decoherence, challenging their merits for practical situations.Quantum illumination (QI) is an entanglement-enhanced paradigm for target detection that thrives on entanglementbreaking loss and noise [15][16][17][18][19][20][21][22]. Its optimum quantum receiver enjoys a 6 dB advantage in error-probability exponent over optimum classical sensing using the same transmitted photon number. Remarkably, QI's advantage occurs despite the initial entanglement being completely destroyed.To date, the only in-principle realization of QI's optimum quantum receiver requires a Schur transform on a quantum computer [23], so that its physical implementation is unlikely to occur in the near future. At present, the best known suboptimum QI receivers [20,21]-one of which, the optical parametric amplifier (OPA) receiver, has been