A gravity-based three-dimensional compass in the mouse brain

Angelaki, Dora E.; Ng, J; Abrego, Amada M.; Cham, Henry X.; Asprodini, Eftihia; Dickman, J. David; Laurens, Jean

doi:10.1038/s41467-020-15566-5

Cited by 36 publications

(21 citation statements)

References 61 publications

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“…Such cells were previously discovered in subcortical structures such as the lateral mammillary nucleus (Stackman and Taube, 1998) and dorsal tegmental nucleus (Bassett and Taube, 2001;Sharp et al, 2001). There is, however, also evidence for such cells in the cortex (Angelaki et al, 2020;Cho and Sharp, 2001;Sharp, 1996;Wilber et al, 2014). Here, we show that AHV cells are far more common in cortical circuits than previously thought.…”

Section: Discussionsupporting

confidence: 48%

Mapping vestibular and visual contributions to angular head velocity tuning in the cortex

Hennestad

Witoelar

Chambers

et al. 2021

Preprint

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Neurons that signal the direction and angular velocity of head movements (AHV cells) are critically important to process visual and spatial information. However, it has been challenging to isolate the sensory modality that drives them and to compre hensively map their cortical distribution. To address this, we developed a method that enables rotating awake, head-fixed mice under a two-photon microscope in a visual environment. Starting in layer 2/3 of the retrosplenial cortex, a key area for vision and navigation, we found that a significant fraction of rotation sensitive neurons report AHV. These tuning properties depend on vestibular input because they persist in darkness and are reduced when replaying visual flow to stationary animals. When mapping the spatial extent, we found AHV cells in all cortical areas that we explored, including motor, somatosensory, visual and posterior parietal cortex. Notably, the vestibular and visual contributions to AHV are area dependent. Thus, many cortical circuits have access to AHV, enabling a diverse integration with sensorimotor and cognitive information.

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Section: Discussionsupporting

confidence: 48%

Mapping vestibular and visual contributions to angular head velocity tuning in the cortex

Hennestad

Witoelar

Chambers

et al. 2021

Preprint

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“…“Head direction” cells, whose firing encodes head position in the azimuth plane 9 – 14 , have been well-documented in multiple brain regions and species, however only a few studies have analyzed coding of other aspects of head and eye movements in brain regions associated with navigation. Neurons in the presubiculum of bats, and the thalamus and retrosplenial cortex of rodents, encode head movements not just in the azimuthal plane, but in the pitch and roll planes as well 14 , 15 . In primates, neurons encoding eye position have been reported in the medial entorhinal cortex (MEC), a key node of the brain’s navigation circuitry 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

et al. 2021

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Neural circuits generate representations of the external world from multiple information streams. The navigation system provides an exceptional lens through which we may gain insights about how such computations are implemented. Neural circuits in the medial temporal lobe construct a map-like representation of space that supports navigation. This computation integrates multiple sensory cues, and, in addition, is thought to require cues related to the individual’s movement through the environment. Here, we identify multiple self-motion signals, related to the position and velocity of the head and eyes, encoded by neurons in a key node of the navigation circuitry of mice, the medial entorhinal cortex (MEC). The representation of these signals is highly integrated with other cues in individual neurons. Such information could be used to compute the allocentric location of landmarks from visual cues and to generate internal representations of space.

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“…As to rotation signals, the distributed preferred axis tends to bias around pitch and roll, but not yaw. A previous study has reported that in mice, azimuth-tuning of head direction cells is affixed to the head-horizontal plane when the animals’ head positions were changed relative to gravity (Dora E. Angelaki et al, 2020). Therefore, these rotation signals could be essential for head direction cells to function properly in 3D environments.…”

Section: Discussionmentioning

confidence: 99%

Robust vestibular self-motion signals in macaque posterior cingulate region

Liu

Tian

2020

Preprint

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Self-motion signals, distributed ubiquitously across parietal-temporal lobes, propagate to limbic hippocampal system for vector-based navigation via hubs including posterior cingulate cortex (PCC) and retrosplenial cortex (RSC). Although numerous studies have indicated that posterior cingulate areas are involved in spatial tasks, it is unclear about how their neurons represent self-motion signals. By providing translation and rotation stimuli to macaques on a 6-degree-of-freedom motion platform, we discovered robust vestibular responses in PCC. A combined 3-dimensional spatiotemporal model captured data well and revealed multiple temporal components including velocity, acceleration, jerk, and position. The former three signals, but not position, conveyed consistent spatial information. Compared to PCC, RSC contained moderate vestibular temporal modulations and lacked significant spatial tuning. Visual self-motion signals were much weaker in both regions compared to the vestibular signals. We conclude that macaque posterior cingulate region carries vestibular-dominant self-motion signals with plentiful temporal components that could be useful for path integration.

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A gravity-based three-dimensional compass in the mouse brain

Cited by 36 publications

References 61 publications

Mapping vestibular and visual contributions to angular head velocity tuning in the cortex

Mapping vestibular and visual contributions to angular head velocity tuning in the cortex

Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

Robust vestibular self-motion signals in macaque posterior cingulate region

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