A “green pathway” different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems

Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body

“…2, Videos 4, 5, online). The current imaging data supported the conclusions from previous studies [11,12] and suggested the difference between the STPs and lymphatic vessels. Due to a lack of commercial lymphotropic paramagnetic tracers that are approved for use in humans and to the difficulties of acquiring biopsies in volunteers, further direct histological studies in humans are strongly warranted.…”

Porous Matrix Stiffness Modulates Response to Targeted Therapy in Breast Carcinoma

“…[ 2 ] In the view of the materials, the cell and its substrates can be considered a hierarchical multiphase porous matrix, [ 3 ] which is well positioned to meet their functions. Matrix structures can also be treated as a biphasic material consisting of a porous elastic solid meshwork bathed in an interstitial fl uid, resulting in a non-Newtonian rheology consistent with a soft matter system that can control fl uid fl ow through/within the porous structure.…”

“…As a crucial mechanical factor, the stiffness of the extracellular matrix (ECM) with micro/nanoscale structures plays an important role in many biological processes such as cell growth, viability, and differentiation . In the view of the materials, the cell and its substrates can be considered a hierarchical multiphase porous matrix, which is well positioned to meet their functions. Matrix structures can also be treated as a biphasic material consisting of a porous elastic solid meshwork bathed in an interstitial fluid, resulting in a non‐Newtonian rheology consistent with a soft matter system that can control fluid flow through/within the porous structure.…”

Intervaginal space injection of a liquid metal can prevent breast cancer invasion and better-sustain concomitant resistance

“…In recent years, the biological utilisation of the intervaginal space in medical applications has been emerging. [17][18][19][20] In particular, a previous study on the flow behavior of LMs in the connected fascial space (FS) showed that the IS in the FS system is a potential pathway to deliver drugs targeting certain regions of the body. 19 In this study, we introduced an LM, a gallium-based alloy, as an obstruction to reduce the CW invasion of BC in breast tumor-bearing mice.…”