A green procedure for the synthesis of 1,8‐dioxodecahydroacridine derivatives under microwave irradiation in aqueous media without catalyst

Abstract

A green procedure for the synthesis of 1,8‐dioxo‐decahydroacridine derivatives is developed under microwave irradiation without catalyst in water. This method provides several advantages such as excellent yields (86–96%), simple workup procedure, and environment friendliness. J. Heterocyclic Chem., (2010).

Efficient and Convenient Synthesis of 1,8‐Dioxodecahydroacridine Derivatives Using Cu‐Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent‐Free Conditions

“…Some methods are available in the literature for the synthesis of acridine derivatives containing 1,4-dihydropyridines, from dimedone, aldehyde, and different nitrogen sources like urea [ 12 ], methyl amine [ 13 ], and different anilines or ammonium acetate [ 14 ] via traditional heating in organic solvents in the presence of triethylbenzylammonium chloride (TEBAC) [ 15 ], p -dodecylbenzenesulfonic acid (DBSA) [ 16 ], Proline [ 17 ], Amberlyst-15 [ 18 ], ammonium chloride, Zn(OAc) 2 ·H 2 O or L-proline [ 19 ], and/or under solvent-free conditions such as under microwave irradiation [ 20 – 22 ], sulfonic acid functionalized silica [ 23 ], ZnO nanoparticles [ 24 ], and nano-Fe 3 O 4 [ 25 ] and using ionic liquids [ 26 , 27 ] such as 1-methylimidazolium trifluoroacetate ([Hmim]TFA) [ 28 ] and Bronsted acidic imidazolium salts containing perfluoroalkyl tails [ 29 ]. Furthermore, some of these procedures suffer from other disadvantages, including the requirement for an expensive catalyst or the use of an excess of catalyst.…”