Bioinformatics grid has emerged to meet the sharp requirement for computation and storage resource in the bioinformatics research field. In this paper, a design of SOA-based bioinformatics grid system is put forward under the WSRF specification. It aggregates existing tools such as BLAST, wrapped as Web Services, through WS-ServiceGroup, and supports the development, deployment, execution and monitoring of complex bioinformatics grid application. Based on the supporting environment, applications can access bioinformatics resource in a transparent manner. This paper also presents a use case to show the process of workflow building, execution and monitoring.