A group-targeting biosensor for sensitive and rapid detection of quinolones in water samples

Wang, Bohan; Liu, Lanhua; Zhang, Haopeng; Wang, Zhiqiang; Chen, Kang; Wu, Bo; Hu, Limin; Zhou, Xiaohong; Liu, Lanlan

doi:10.1016/j.aca.2024.342475

Analytica Chimica Acta

2024

DOI: 10.1016/j.aca.2024.342475

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A group-targeting biosensor for sensitive and rapid detection of quinolones in water samples

Bohan Wang,

Lanhua Liu,

Haopeng Zhang

et al.

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Cited by 4 publications

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Detection of Estrogen Receptor Status in Breast Cancer Cytology Samples by an Optical Nanosensor

Gaikwad,

Rahman,

Ghosh

et al. 2024

Advanced NanoBiomed Research

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Breast cancer is a substantial source of morbidity and mortality worldwide. Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) are the primary biomarkers which inform breast cancer treatment. Although endocrine therapy for ER+ patients is widely available, there is a need for increased access to low‐cost, rapid, and accurate ER testing methods. In this work, we designed a near‐infrared optical nanosensor using single‐walled carbon nanotubes (SWCNT) as the transducer and an anti‐ERα antibody as the recognition element. We evaluated the nanosensor in vitro prior to testing with 26 breast cancer samples which were collected by scraping the cut surface of fresh, surgically resected tumors. Twenty samples were ER+, and six ER−, representing 13 unique patients. We found that the nanosensor can differentiate ER− from ER+ patient biopsies through a shift in its center wavelength upon sample addition. Receiver operating characteristic area under the curve analyses determined that the strongest classifier with an AUC of 0.94 was the (7,5) SWCNT after direct incubation and measurement, and without further processing. We anticipate that further testing and development of this nanosensor may push its utility toward field‐deployable, rapid ER subtyping with the potential for additional molecular marker profiling.

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Detection of Estrogen Receptor Status in Breast Cancer Cytology Samples by an Optical Nanosensor

Gaikwad,

Rahman,

Ghosh

et al. 2024

Advanced NanoBiomed Research

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The construction of ofloxacin detection in fish matrix based on a shark-derived single-domain antibody

Liu,

Chen,

Lin

et al. 2024

Analytica Chimica Acta

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Confinement and heating promoted RTP of flumequine, oxolinic acid and levofloxacin on papers for their detection and discrimination

Wang,

Shi,

Shen

et al. 2024

Sensors and Actuators B: Chemical

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A group-targeting biosensor for sensitive and rapid detection of quinolones in water samples

Cited by 4 publications

References 44 publications

Detection of Estrogen Receptor Status in Breast Cancer Cytology Samples by an Optical Nanosensor

Detection of Estrogen Receptor Status in Breast Cancer Cytology Samples by an Optical Nanosensor

The construction of ofloxacin detection in fish matrix based on a shark-derived single-domain antibody

Confinement and heating promoted RTP of flumequine, oxolinic acid and levofloxacin on papers for their detection and discrimination

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