A guide to antibiotic resistance in bacterial skin infections

Perera, Gayathri; Hay, R. J.

doi:10.1111/j.1468-3083.2005.01296.x

Cited by 18 publications

(17 citation statements)

References 105 publications

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“…None of these data indicate a significant causal relationship between the short-term use of topical fusidic acid and increasing resistance. However, long-term use of topical antibiotics, including fusidic acid, may lead to emergence of resistant bacteria (28).…”

Section: Ada Derm Venereal 87mentioning

confidence: 99%

An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort® Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis

Larsen¹,

Simonsen²,

Melgaard³

et al. 2007

Acta Derm Venereol

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To relieve the dryness of atopic dermatitis skin, a lipid formulation of fusidic acid and betamethasone 17-valerate (Fucicort Lipid cream) was developed as an additional treatment option to the established Fucicort cream. The two formulations were compared in patients with clinically infected atopic dermatitis. A total of 629 patients were randomized to twice daily double-blind treatment for 2 weeks with either Fucicort Lipid cream, Fucicort cream, or the new lipid cream vehicle. Clinical assessment was based on a Total Severity Score of the eczematous lesions. Bacteriological samples were taken at inclusion and at subsequent visit(s) if clinically infected lesions persisted. At the end of treatment, the mean reduction in Total Severity score was 82.9% in the lipid cream group, 82.7% in the cream group, and 33.0% in the vehicle group. The percentage of patients with a successful bacteriological response was 89.7%, 89.6% and 25.0%, respectively. Thus, the clinical and anti-bacterial effect of the lipid cream was found to be similar to that of the established cream formulation, and significantly better than that of the vehicle. The new lipid formulation, therefore, offers an efficient, safe and well-tolerated alternative for the short-term treatment of clinically infected atopic dermatitis.

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Section: Ada Derm Venereal 87mentioning

confidence: 99%

An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort® Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis

Larsen¹,

Simonsen²,

Melgaard³

et al. 2007

Acta Derm Venereol

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“…15 The composition of normal skin flora varies depending on their location, with the face, neck, and hands often having a higher bacterial density than other areas of the body that are less exposed to the environment. 16 Additional factors that influence an individual's microflora include gender, race or ethnicity, hospitalization, personal hygiene, use of medications, and exposure to ultraviolet light.…”

Section: Bacteria Involved In Uncomplicated Skin and Skin Structure Imentioning

confidence: 99%

“…13 They can be triggered by friction, scratching, pressure, or hyperhidrosis and commonly affect the groin, nasal cavity, scalp, and external auditory canal. [14][15][16] 212 Clinical Pediatrics / Vol. 47 Furunculosis is relatively uncommon in early childhood, but its incidence is increased in adolescents, particularly those living in crowded conditions with poor hygiene.…”

mentioning

confidence: 99%

Uncomplicated Skin and Skin Structure Infections in Children: Diagnosis and Current Treatment Options in the United States

Silverberg

Block

2008

Clin Pediatr (Phila)

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treatment that allows pathogenic bacteria to multiply on the skin. 4,5 Uncomplicated SSSIs can occur in the various layers of the skin (Figure 1) and in underlying tissue, and they are classified as primary infections, such as impetigo, or as secondary infections of existing lesions, which include atopic dermatitis, allergic contact dermatitis, and psoriasis. Infections occurring in lacerations, sutured wounds, and abrasions are also classified as secondary infections. The features of the most common uncomplicated SSSIs are described below (Table 1).Impetigo is a highly contagious, superficial, pyogenic skin infection that presents as either a bullous or a nonbullous form. Nonbullous impetigo accounts for more than 70% of cases and is characterized by small vesicles or pustules that rupture and develop a yellow-brown crust. 6 The bullous form is common among newborns but may affect any age-group. Bullous impetigo presents as flaccid bullae (blisters), which rupture easily and leave erythematous lesions. The areas most commonly affected by impetigo are moist, intertriginous regions, such as the neck folds, nose, groin, and axillae. 6 Impetigo can occur either as a primary infection or as a secondary infection to another condition that disrupts the skin barrier, such as impetiginized atopic dermatitis.Atopic dermatitis is a common chronic inflammatory skin disease, which has become increasingly prevalent in recent years. 7 The primary lesions in atopic dermatitis are associated with a high prevalence

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“…Its treatment involves systematic antibiotics and local adjuvants. However, the prevalence of antibiotic resistance in bacteria with penicillin, erythromycin, tetracycline, fusidic acid, methicillin, vancomycin, and glycopeptides are more common [4]. Thus, there is a need of an effective and safe alternative treatment for treating skin infections caused by Streptococci and Staphylococci.…”

Section: Introductionmentioning

confidence: 99%

Size Dependent Application of Biologically Synthesized Silver Nanoparticles Against Bacterial Skin Pathogens

Patil

Palaniswamy

2017

Asian J Pharm Clin Res

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Objective: Bacterial skin infection is one of the most common causes of childhood morbidity in India. Mostly, it is caused by Streptococcus and Staphylococcus infections. However, because of antibiotic resistance in bacterial strains, treatment of skin infections is becoming increasingly difficult. The objective of this research is to study the effect of plant extract concentration on synthesis and morphology of biological silver nanoparticles and investigation of their activity against bacterial skin pathogens.Methods: Biological silver nanoparticles were synthesized using two concentrations (5 and 10 ml) of Aegle marmelos fruit pulp extract. Ultraviolet (UV)-visible spectroscopy, field emission scanning microscopy (FESEM), and high resolution transmission electron microscopy (HRTEM) were used to analyze morphological features of nanoparticles. Antibacterial activity of synthesized silver nanoparticles was studied against the most common skin pathogens Staphylococcus aureus and Streptococcus pyogen, using a well diffusion method.Results: The silver nanoparticles synthesized from 5 ml extract showed UV-absorbance peak at 430 nm with 14-18 nm size, while silver nanoparticles synthesized from 10 ml extract was showed the absorbance at 427 nm with 4-8 nm size. FESEM and HRTEM analysis revealed that both the silver nanoparticles were spherical in shape. Both nanoparticles have shown antibacterial activity among them silver nanoparticles synthesized from 10 ml extract showed better antibacterial activity.Conclusion: This research confirms that plant extract concentration modulate the rate of synthesis, morphology, surface plasmon resonance, and activity of biological silver nanoparticles. Silver nanoparticles synthesized from 10 ml extract can be used efficiently in the treatment of bacterial skin infections.

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A guide to antibiotic resistance in bacterial skin infections

Cited by 18 publications

References 105 publications

An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort® Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis

An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort® Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis

Uncomplicated Skin and Skin Structure Infections in Children: Diagnosis and Current Treatment Options in the United States

Size Dependent Application of Biologically Synthesized Silver Nanoparticles Against Bacterial Skin Pathogens

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