2024
DOI: 10.1002/1878-0261.13649
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A guide to ferroptosis in cancer

Fatma Isil Yapici,
Christina M. Bebber,
Silvia von Karstedt

Abstract: Ferroptosis is a newly identified iron‐dependent type of regulated cell death that can also be regarded as death caused by the specific collapse of the lipid antioxidant defence machinery. Ferroptosis has gained increasing attention as a potential therapeutic strategy for therapy‐resistant cancer types. However, many ferroptosis‐inducing small molecules do not reach the pharmacokinetic requirements for their effective clinical use yet. Nevertheless, their clinical optimization is under development. In this rev… Show more

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