A guide to the design of magnetic particle imaging tracers for biomedical applications

Duong, Hong Thien Kim; Abdibastami, Ashkan; Gloag, Lucy; Barrera, Liam; Gooding, J. Justin; Tilley, Richard D.

doi:10.1039/d2nr01897g

Cited by 23 publications

(9 citation statements)

References 157 publications

(361 reference statements)

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“…The obtained value of longitudinal relaxivity ( r 1 ) is 0.46 s –1 mM –1 and transverse relaxivity ( r 2 ) is 15.94 s –1 mM –1 , resulting in an r 2 / r 1 of 34.65. As the achieved value is higher than 10, it suggests the dominance of transverse relaxivity. − In addition, to understand the relaxivity of pristine ZnFe 2 O 4 , the relaxivity study is performed and the details are provided in Supporting Information file, Figures S6, and S7. However, r 1 and r 2 for bare ZnFe 2 O 4 at 1.4 T is found as 0.25 s –1 mM –1 and 6.81 s –1 mM –1 with r 2 / r 1 of 27.2.…”

Section: Resultsmentioning

confidence: 99%

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe₂O₃@ZnFe₂O₄

Konwar,

Kaushik,

Babu

et al. 2024

Langmuir

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The potential application of magnetic nanosystems as magnetic resonance imaging (MRI) contrast agents has been thoroughly investigated. This work seeks to attain robust MRIcontrast efficiency by designing an interacting landscape of a bimagnetic ensemble of zinc ferrite nanorods and maghemite nanoparticles, γ-Fe 2 O 3 @ZnFe 2 O 4 . Because of competing spin clusters and structural anisotropy triggered by isotropic γ-Fe 2 O 3 and anisotropic ZnFe 2 O 4 , γ-Fe 2 O 3 @ZnFe 2 O 4 undergoes the evolution of cluster spin-glass state as evident from the critical slowing down law. Such interacting γ-Fe 2 O 3 @ZnFe 2 O 4 with spin flipping of 1.2 × 10 −8 s and energy barrier of 8.2 × 10 −14 erg reflects enhanced MRI-contrast signal. Additionally, γ-Fe 2 O 3 @ ZnFe 2 O 4 is cell-viable to noncancerous HEK 293 cell-line and shows no pro-tumorigenic activity as observed in MDA-MB-231, an extremely aggressive triple-negative breast cancer cell line. As a result, γ-Fe 2 O 3 @ZnFe 2 O 4 is a feasible option for an MRI-contrast agent having longitudinal relaxivity, r 1 , of 0.46 s −1 mM −1 and transverse relaxivity, r 2 , of 15.94 s −1 mM −1 , together with r 2 /r 1 of 34.65 at 1.41 T up to a modest metal concentration of 0.1 mM. Hence, this study addresses an interacting isotropic/anisotropic framework with faster water proton decay in MR-relaxivity resulting in phantom signal amplification.

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Section: Resultsmentioning

confidence: 99%

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe₂O₃@ZnFe₂O₄

Konwar,

Kaushik,

Babu

et al. 2024

Langmuir

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“…H S outside this area magnetises the MNPs to a high enough degree to ignore H D 's temporally variable effect on the magnetisation [29,30]. Lastly, the receiving coil is responsible for detecting the changes in magnetisation exhibited by the SPIONs within the FFR [31]. It captures the magnetic signals generated by the SPIONs as they react to the drive field.…”

Section: Principle Of Mpimentioning

confidence: 99%

Advancement of magnetic particle imaging in diagnosis and therapy

Harini,

Girigoswami,

Pallavi

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Magnetic particle imaging (MPI) has gained significant traction as an ionising radiation-free tomographic method that offers real-time imaging capabilities with enhanced sensitivity and resolutions. In this technique, magnetic nanoparticles (MNPs) are employed, particularly iron oxide nanoparticles with superparamagnetic nature, as probes within the MPI system. These MNPs enable the tracking and precise quantification of particle movement with minimal background noise. The 3D location and concentration of MNPs can provide better insights for multiple applications in vascular imaging, cell tracking, cancer cell imaging, inflammation, implant monitoring, and trauma imaging and can thus accelerate the diagnosis of disorders. The mononuclear phagocyte system provides a significant advantage, as they are involved in the spontaneous clearance of the tracers used in MPI, which readily minimise the toxic effects. Several studies have demonstrated that MPI-based functional neuroimaging is superior to other imaging modalities, providing adequate temporal resolution images with quick scan intervals. In MPI, nanoparticles are solely responsible for the source and visualisation, unlike magnetic resonance imaging (MRI), where nanoparticles were used only as supportive tracers. This review provides an overview of the principle, diagnostic, and therapeutic applications of MPI as well as the advantages and challenges MPI has over other diagnostic imaging methods in modern clinical setups.

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“…The area enclosed by a hysteresis loop plays a central role in biomedical applications, being related to the energy absorbed by the particles from the applied field in one period, which acts to increase their temperature and finally results in a net transfer of heat to the environment. In some cases, as in magnetic hyperthermia [61], such a heat is instrumental to the effectiveness of the therapy and has to be maximized and/or controlled; on the contrary the release of heat can be an unnecessary side effect or even a nuisance in other applications, such as MPI [62], so that in these cases the loop area should be minimized.…”

Section: Hysteresis Loop's Areamentioning

confidence: 99%

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

Barrera

Tiberto

2023

J. Phys. Mater.

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An innovative method is proposed to determine the most important magnetic properties of bioapplication-oriented magnetic nanomaterials exploiting the connection between hysteresis loop and frequency spectrum of magnetization. Owing to conceptual and practical simplicity, the method may result in a substantial advance in the optimization of magnetic nanomaterials for use in precision medicine. The techniques of frequency analysis of the magnetization currently applied to nanomaterials both in vitro and in vivo usually give a limited, qualitative picture of the effects of the active biological environment on magnetic tracers, and have to be complemented by direct measurement of the hysteresis loop. We show that the very same techniques can be used to convey all the information needed by present-day biomedical applications without the necessity of doing conventional magnetic measurements in the same experimental conditions. The spectral harmonics obtained analyzing the response of a magnetic tracer in frequency, as in Magnetic Particle Spectroscopy/Imaging (MPS/MPI), are demonstrated to lead to a precise reconstruction of the hysteresis loop, whose most important parameters (loop's area, magnetic remanence and coercive field) are directly obtained through transformation formulas based on simple manipulation of the harmonics amplitudes and phases.The validity of the method is experimentally verified on various magnetic nanomaterials for bioapplications submitted to ac magnetic fields of different amplitude, frequency and waveshape. In all cases, the experimental data taken in the frequency domain exactly reproduce the magnetic properties obtained from conventional magnetic measurements.

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A guide to the design of magnetic particle imaging tracers for biomedical applications

Abstract: Magnetic Particle Imaging (MPI) is a novel and emerging non-invasive technique that promises to deliver high quality images, no radiation, high depth penetration and nearly no background from tissues. Signal...

Cited by 23 publications

References 157 publications

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe₂O₃@ZnFe₂O₄

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe₂O₃@ZnFe₂O₄

Advancement of magnetic particle imaging in diagnosis and therapy

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

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A guide to the design of magnetic particle imaging tracers for biomedical applications

Abstract: Magnetic Particle Imaging (MPI) is a novel and emerging non-invasive technique that promises to deliver high quality images, no radiation, high depth penetration and nearly no background from tissues. Signal...

Cited by 23 publications

References 157 publications

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe2O3@ZnFe2O4

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe2O3@ZnFe2O4

Advancement of magnetic particle imaging in diagnosis and therapy

From spectral analysis to hysteresis loops: a breakthrough in the optimization of magnetic nanomaterials for bioapplications

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Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe₂O₃@ZnFe₂O₄

Integrative Modulation of Magnetic Resonance Transverse and Longitudinal Relaxivity in a Cell-Viable Bimagnetic Ensemble, γ-Fe₂O₃@ZnFe₂O₄