A Handy Clue: Palmar Fasciitis and Polyarthritis Syndrome

Mahoney, Kyle; Cayea, Danelle; Li, Qing Kay; Gelber, Allan C.

doi:10.1016/j.amjmed.2013.09.021

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…The role of soluble stimulators of fibroblast activity such as transforming growth factor β (TGF-β) or connective tissue growth factor has been reported (5,23,24). However, because the relationship between Dupuytren's disease and TGF-β had also been shown (25), differences in the TGF-β levels cannot explain the different etiologies of palmar fibromatosis or fasciitis associated with cancer and Dupuytren's disease.…”

Section: Discussionmentioning

confidence: 86%

Fallopian Tube Cancer with Palmar Fibromatosis or Fasciitis without Polyarthritis

et al. 2015

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A 64-year-old Japanese woman had rapidly progressing bilateral palmar contracture associated with severe pain on both palms over the previous 8 weeks, without a history of arthritis in any joints. We suspected palmar fibromatosis or fasciitis without polyarthritis. Because palmar fibromatosis is known to be associated with cancer, we performed cancer screening and the patient was subsequently diagnosed with fallopian tube cancer. This is the first case report of palmar fibromatosis or fasciitis without polyarthritis associated with fallopian tube cancer. The characteristic rapid progression of palmar contracture is a key finding that suggests the potential existence of a malignancy.

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Section: Discussionmentioning

confidence: 86%

Fallopian Tube Cancer with Palmar Fibromatosis or Fasciitis without Polyarthritis

et al. 2015

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“…PFPAS should be considered in cases of acute-or subacute-onset symmetrical flexion contractures of both hands and polyarthritis, particularly with seronegativity and in the absence of Raynaud's phenomenon (11), as the combination of seronegative arthritis and the absence of Raynaud's phenomenon is atypical for rheumatoid arthritis, scleroderma, mixed connective tissue disease, and systemic . Although the information from skin biopsies and MRI is helpful, these findings do not permit a definite diagnosis of PFPAS (4).…”

Section: B a Cmentioning

confidence: 99%

Palmar Fasciitis and Polyarthritis Syndrome Associated with Lung Adenocarcinoma

et al. 2022

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Palmar fasciitis and polyarthritis syndrome (PFPAS) is a rare paraneoplastic rheumatic disease with characteristic features. We herein report a 77-year-old man with lung adenocarcinoma and contralateral pulmonary metastasis receiving chemotherapy who presented with progressive symmetrical flexion contractures associated with palmar fascial thickening and arthritis of both hands and shoulders. He was diagnosed with PFPAS as paraneoplastic manifestations. Salazosulfapyridine was not effective, but 15 mg/day of oral prednisolone improved his symptoms. Physicians should consider PFPAS and rule out malignancy in patients with arthritis in the extremities and flexion contractures associated with palmar fascial thickening.

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