A Head-to-Head Comparison of Hydrogen Peroxide Vapor and Aerosol Room Decontamination Systems

Abstract

One HPV generator was more effective than 2 aHP machines for the inactivation of G. stearothermophilus BIs, and cycle times were faster for the HPV system.

The role of ‘no-touch’ automated room disinfection systems in infection prevention and control

“…11,62 One manufacturer (ASP Glosair) states a particle size of 8e10 mm whereas another manufacturer (Oxypharm Nocospray) states a smaller particle size of 0.5 mm. 63,69,70 The dose typically recommended for hospital rooms is 6 mL/m 3 , although multiple cycles of this dose have been used in several studies. 69,71 Following exposure, the aerosol is left to decompose naturally without any active aeration system.…”

Reply to Roberts

“…A 6-log kill is definitely appropriate for terminal sterilization of critical medical devices if the devices are used in normally sterile body sites. 2 The goal of room decontamination is significantly different: to eliminate potentially pathogenic microorganisms contaminating room surfaces.…”

“…9 Finally, our study showed incomplete distribution from one of the systems. 10 This means that some areas of a hospital room get a lower dose of hydrogen peroxide than do other areas, which could contribute to the fact that log reductions achieved in vitro are not realized in all parts of the room. There is perhaps a parallel with liquid cleaning and disinfectants, in which more than a 2-log reduction in vitro does not eradicate pathogens because of limitations in achieving adequate distribution and contact time.…”

An Investigation into the Inactivation Kinetics of Hydrogen Peroxide Vapor Against Clostridium difficile Endospores

“…These comprise either stamped metal discs or papers onto which spore suspensions of either Bacillus subtilis, or more commonly Geobacillus stearothermophilus, have been deposited. A number of studies on the efficacy of HPV generators have been conducted using commercial BIs, e.g., Fu et al (2012) and Holmdahl et al (2011). Moreover, published studies routinely fail to provide details of the spatial and temporal HPV concentrations achieved during decontamination.…”