A head-to-head comparison of the degradation rate of resorbable bioceramics

Hsu, Pei‐Yi; Kuo, Hung‐Chi; Syu, Man-Lin; Tuan, Wei‐Hsing; Lai, Po‐Liang

doi:10.1016/j.msec.2019.110175

Cited by 23 publications

(27 citation statements)

References 14 publications

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“…Few in vitro studies continue degradation testing beyond 28 days [ 12 , 18 , 19 ]. However, bone defects typically take much longer to heal so the degradation behavior should be monitored over a much longer time period.…”

Section: Resultsmentioning

confidence: 99%

“…The degradation of calcium sulfate hemihydrate discs may be even more unpredictable. Hsu et al applied a sintering technique to remove the pores and crystal water from the calcium sulfate hemihydrate structure, resulting in a significant reduction in the material’s degradation rate [ 12 ]. As demonstrated in the present study, the sintered CaSO 4 specimen degraded 23% after 28 days, then another 25% from weeks 5 to 12 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…The use of such sintered discs gives us chance to evaluate the effect of Sr content. The degradation of calcium sulfate generates calcium phosphate at the surface during degradation [ 12 ]. Therefore, the degradation rate decreases over time due to the change from calcium sulfate to calcium phosphate on the surface.…”

Section: Discussionmentioning

confidence: 99%

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Long-term in vitro degradation and in vivo evaluation of resorbable bioceramics

Chen

Hsu

Tuan

et al. 2021

J Mater Sci: Mater Med

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An essential criterion for the selection of resorbable bioceramics is their ability to degrade inside human body within a reasonable time frame. Furthermore, if the bioceramic can release beneficial ions, such as strontium, as it degrades, recovery time might be shortened. The present study demonstrates that strontium-containing calcium sulfate (Sr,Ca)SO4 can fulfill these criteria. A long-term in vitro degradation analysis for 12 weeks using sintered (Sr,Ca)SO4 discs in phosphate buffered solution (PBS) was conducted. The sintered (Sr,Ca)SO4 disc was then implanted into defects in the distal femur of rats. The degradation rate of (Sr,Ca)SO4 discs showed a strong dependence on the Sr content. Similar results were observed between the long-term in vitro degradation analysis and the in vivo evaluation. The sintered (3.8%Sr,Ca)SO4 disc lost more than 80% of its initial weight after soaking in PBS with shaking at 37 °C for 12 weeks. After 12 weeks in vivo, the remaining volume of the (3.8%Sr,Ca)SO4 disc within the bone defect was ~25%. Over the same time period, new bone was formed at a relative volume of 40%. This study demonstrates the potential of (Sr,Ca)SO4 bioceramic, and the benefits of using a long-term degradation test during the evaluation of resorbable bioceramics.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Long-term in vitro degradation and in vivo evaluation of resorbable bioceramics

Chen

Hsu

Tuan

et al. 2021

J Mater Sci: Mater Med

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“…However, the amount of releasing Sr depended on the material of the carrier, depended also on the type of aqueous solution. Since the degradation rate of calcium phosphate and bioglass was usually slow [13], the amount of Sr could be released from these calcium salts was therefore low (Table 1). Furthermore, a design rule for Sr-containing carrier is still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Calcium sulfate has been used as bone void filler for over 100 years. An in vitro test over a time span of 28 days demonstrated a steady degradation rate [13,14]. Complete degradation may take up to 3 months, which is about the time needed for the recovery of a bone defect.…”

Section: Introductionmentioning

confidence: 99%

From phase diagram to the design of strontium-containing carrier

Chen

Hsu

Tuan

et al. 2020

Journal of Asian Ceramic Societies

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Strontium (Sr) ions are known for its role on increasing bone mineral density. However, a high dosage through mouth may cause many side effects. An alternative to provide a low but steady release at the location of bone defect is therefore explored. In the present study, various amounts of strontium sulfate (SrSO 4) were dissolved into calcium sulfate (CaSO 4) at elevated temperatures. The release of Sr ions from the (Ca,Sr)SO 4 solid solution into various aqueous solutions was then measured. Through the control of Sr content in (Ca,Sr)SO 4 , the Sr amount releasing into the aqueous solutions could be tailored. After implanting a solid solution into distal femur in rat, a low release of Sr into blood was confirmed.

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