A head-to-head comparison review of biological and toxicological studies of isomaltulose,<scp>d</scp>-tagatose, and trehalose on glycemic control

Sokołowska, Emilia; Sadowska, Anna; Sawicka, Diana; Kotulska-Bąblińska, Izabela; Car, Halina

doi:10.1080/10408398.2021.1895057

Cited by 29 publications

(30 citation statements)

References 195 publications

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“…According to recent findings, alleviating effects of trehalose in diabetes can result from the improvement of glycemic control and insulin response [55], increased rate of autophagy [56,57], protective effect against oxidative stress [58], as well as influence on gut microbiota [59]. Therefore, trehalose was suggested as a potential preventive therapy for metabolic syndrome and diabetes development [60].…”

Section: Discussionmentioning

confidence: 99%

Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice

Короленко¹,

Дубровина²,

Ovsyukova³

et al. 2021

Cells

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Autophagy attenuation has been found in neurodegenerative diseases, aging, diabetes mellitus, and atherosclerosis. In experimental models of neurodegenerative diseases, the correction of autophagy in the brain reverses neuronal and behavioral deficits and hence seems to be a promising therapy for neuropathologies. Our aim was to study the effect of an autophagy inducer, trehalose, on brain autophagy and behavior in a genetic model of diabetes with signs of neuronal damage (db/db mice). A 2% trehalose solution was administered as drinking water during 24 days of the experiment. Expressions of markers of autophagy (LC3-II), neuroinflammation (IBA1), redox state (NOS), and neuronal density (NeuN) in the brain were assessed by immunohistochemical analysis. For behavioral phenotyping, the open field, elevated plus-maze, tail suspension, pre-pulse inhibition, and passive avoidance tests were used. Trehalose caused a slight reduction in increased blood glucose concentration, considerable autophagy activation, and a decrease in the neuroinflammatory response in the brain along with improvements of exploration, locomotor activity, anxiety, depressive-like behavior, and fear learning and memory in db/db mice. Trehalose exerted some beneficial peripheral and systemic effects and partially reversed behavioral alterations in db/db mice. Thus, trehalose as an inducer of mTOR-independent autophagy is effective at alleviating neuronal and behavioral disturbances accompanying experimental diabetes.

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Section: Discussionmentioning

confidence: 99%

Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice

Короленко¹,

Дубровина²,

Ovsyukova³

et al. 2021

Cells

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“…Taya et al (36) disclose that trehalose is capable of reducing the production of in ammatory cytokines by protecting IkappaB-alpha reduction in vivo. Since hyperglycemia and in ammation are essential pathogenic factors contributing to DR and the safety of trehalose has been con rmed (35), we presume that trehalose supplementation may be bene cial to DR prevention and control. Further studies should be conducted to verify this presumption.…”

Section: Discussionmentioning

confidence: 92%

“…To the best of our knowledge, this is the rst report to detect a connection of trehalose with DR. In fact, trehalose cannot be synthesized in human body and mainly used in Asian countries as a food stabilizer (35). Existing evidence reveals that trehalose can effectively govern hyperglycemia of diabetic patients via relieving impaired glucose tolerance, mitigating insulin resistance, and reducing postmeal insulin bursts (35).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, trehalose cannot be synthesized in human body and mainly used in Asian countries as a food stabilizer (35). Existing evidence reveals that trehalose can effectively govern hyperglycemia of diabetic patients via relieving impaired glucose tolerance, mitigating insulin resistance, and reducing postmeal insulin bursts (35). Taya et al (36) disclose that trehalose is capable of reducing the production of in ammatory cytokines by protecting IkappaB-alpha reduction in vivo.…”

Section: Discussionmentioning

confidence: 99%

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Identification of Metabolic Pathway Dysregulation in Diabetic Retinopathy: A Propensity Score-Matched Metabolomic Study

Guo

Jiang

et al. 2021

Preprint

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Background Diabetic retinopathy (DR) is a major diabetes-related disease linked to metabolism. However, scientifically assessment of serum metabolic alterations in DR is scarce. We aimed to investigate the changes in metabolic coregulation from type 2 diabetic patients (T2DM) to DR and identify corresponding metabolite predictors via a widely targeted metabolomics approach.Methods In this case-control study, we tested 613 serum metabolites in 69 pairs of T2DM with DR (case) and propensity score-matched T2DM without DR (control) utilizing the ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry system. The discrimination capability of differentially expressed metabolites (DEMs) in DR identification was also evaluated using a least absolute shrinkage and selection operator (LASSO) regression-based linear support vector machine (SVM) classifier. Metabolic pathway dysregulation in DR were comprehensively investigated by metabolic pathway analysis, chemical similarity enrichment analysis and MetaMapp approaches.Results A total of 89 DEMs were identified after paired univariate analysis and partial least squares discriminant analysis. The linear-SVM model based on LASSO regression selected DEMs had an excellent discrimination with an area under the ROC curve (AUC) as 0.99 (95% confidence interval: 0.95, 1.00). The biosynthesis of polyunsaturated fatty acids (PUFAs), thiamine metabolism, amino acids (mainly glycine, serine and threonine metabolism), hydroxyeicosatetraenoic acid (HETE), disaccharides, indoles and nucleotides were significantly enriched in DR. Conclusions This study systematically demonstrates that distinct metabolic alterations are linked to DR initiation. n-3 PUFAs, trehalose and vitamin B1 play an important role in inhibiting DR progression.

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“… 1 , 3 This disaccharide was generally recognized as safe (GRAS) in 2000 by the Food & Drug Administration (FDA, USA), with an equivalent sweetness of 45% sucrose and being mainly used in the food industry as a sweetener, stabilizer, and moisturizer. 4 In this context, it is important to emphasize its high stability in terms of temperature and pH. In addition, its α-bond is not hydrolyzed by the pancreatic α-amylase, and it has considerable resistance to acids.…”

Section: Introductionmentioning

confidence: 99%

Enzymatic Synthesis and Structural Characterization of Novel Trehalose-Based Oligosaccharides

Gallego-Lobillo

Doyagüez

Jimeno

et al. 2021

J. Agric. Food Chem.

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Trehalose, α- d -glucopyranosyl-(1↔1)-α- d -glucopyranoside, is a disaccharide with multiple effects on the human body. Synthesis of new trehalose derivatives was investigated through transgalactosylation reactions using β-galactosidase from four different species. β-galactosidases from Bacillus circulans ( B. circulans ) and Aspergillus oryzae ( A. oryzae ) were observed to be the best biocatalysts, using lactose as the donor and trehalose as the acceptor. Galactosyl derivatives of trehalose were characterized using nuclear magnetic resonance spectroscopy. Trisaccharides were the most abundant oligosaccharides obtained followed by the tetrasaccharide fraction (19.5% vs 8.2% carbohydrates). Interestingly, the pentasaccharide [β-Gal p -(1→4)] 3 -trehalose was characterized for the first time. Greater oligosaccharide production was observed using β-galactosidase from B. circulans than that obtained from A. oryzae , where the main structures were based on galactose monomers linked by β-(1→6) and β-(1→4) bonds with trehalose in the ending. These results indicate the feasibility of commercially available β-galactosidases for the synthesis of trehalose-derived oligosaccharides, which might have functional properties, excluding the adverse effects of the single trehalose.

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A head-to-head comparison review of biological and toxicological studies of isomaltulose,d-tagatose, and trehalose on glycemic control

Cited by 29 publications

References 195 publications

Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice

Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice

Identification of Metabolic Pathway Dysregulation in Diabetic Retinopathy: A Propensity Score-Matched Metabolomic Study

Enzymatic Synthesis and Structural Characterization of Novel Trehalose-Based Oligosaccharides

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