A health status assessment of the impact of weight loss following Roux-en-Y gastric bypass for clinically severe obesity

Choban, Patricia S.; Onyejekwe, Jacqueline; Burge, Jean C.; Flancbaum, Louis

doi:10.1016/s1072-7515(99)00030-7

Cited by 138 publications

(85 citation statements)

References 25 publications

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“…Various forms of the SF-36 s have been used in multiple studies of GBS populations, demonstrating consistent improvement with weight loss as early as a few weeks post-operatively. [39][40][41][42][43] Our subjects' results were consistent with these findings. The SF-36 s has been recommended at a consensus conference of bariatric surgeons 44 and the SF-12 s has demonstrated internal validity in a bariatric population.…”

Section: Discussionsupporting

confidence: 90%

Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery

et al. 2006

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Objective: To determine the point prevalence of painful musculoskeletal (MSK) conditions in obese subjects before and after weight loss following bariatric surgery. Design: Longitudinal, interventional, unblended. Subjects: Forty-eight obese subjects (47 women, one man, mean age 4479 years; mean body mass index (BMI) 5178 kg/m 2 ) recruited from an academic medical center bariatric surgery program. Measurements: Comorbid medical conditions; MSK findings; BMI; Western Ontario McMaster Osteoarthritis Index (WOMAC) for pain, stiffness and function; and SF-36 s for quality of life. Methods: Consecutive subjects were recruited from the University Hospitals of Cleveland Bariatric Surgery Program. Musculoskeletal signs and symptoms and non-MSK comorbid conditions were documented at baseline and at follow-up. Subjects completed the SF-36 s and the WOMAC questionnaires. Analyses were carried out for each MSK site, fibromyalgia syndrome (FMS) and for the cumulative effect on the spine, upper and lower extremities. The impact of change in comorbid medical conditions, BMI, physical and mental health domains of the SF-36 s on the WOMAC pain subscale score was evaluated. SF-36 s outcomes were compared to normal published controls. Results: Forty-eight subjects were available for baseline and a follow-up assessment 6-12 months after gastric bypass surgery. They lost an average of 41715 kg and the mean BMI decreased from 5178 to 3677 kg/m 2 . Baseline comorbid medical conditions were present in 96% before surgery and 23% after weight loss. There was an increased prevalence of painful MSK conditions at baseline compared to general population frequencies. Musculoskeletal complaints had been present in 100% of obese subjects before, and 23% after weight loss. The greatest improvements occurred in the cervical and lumbar spine, the foot and in FMS (decreased by 90, 83, 83 and 92%, respectively). Seventy-nine percent had upper extremity MSK conditions before and 40% after weight loss. Before surgery, 100% had lower extremity MSK conditions and only 37% did after weight loss. The WOMAC subscale and composite scores all improved significantly, as did the SF-36 s . Change in BMI was the main factor impacting the WOMAC pain score. Conclusion: There was a higher frequency of multiple MSK complaints, including non-weight-bearing sites compared to historical controls, before surgery, which decreased significantly at most sites following weight loss and physical activity. These benefits may improve further, as weight loss may continue for up to 24 months. The benefits seen with weight loss indicate that prevention and treatment of obesity can improve MSK health and function.

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Section: Discussionsupporting

confidence: 90%

Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery

et al. 2006

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“…Larger weight losses after Lap-Band surgery are associated with greater improvements in Beck Depression Inventory scores. If weight loss typically results in improvements in mood across methods of weight loss (37,38), a treatment that results in sustained weight loss would be expected to improve instead of worsen the mood of the participants. Previous human studies of ecopipam in cocaine-abusing patients did not report any psychiatric adverse effects including depression or suicidality (22,23,39); however, these studies were all of short duration and do not offer sufficient assurance that depression may not occur with the more extended treatment that would be required to treat obesity.…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trials of the D1/D5 Antagonist Ecopipam for Weight Loss in Obese Subjects

Astrup

Greenway

Ling

et al. 2007

Obesity

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“…These data are in accordance with previous studies (Kral et al, 1992) showing that obesity severely degrades QoL, and that post-operative weight loss is usually followed by a significant and early QoL improvement, despite the difficulties to adapt to food restriction and early postoperative pain (Hafner et al, 1991). In another study (Choban et al, 1999), the QoL was assessed by the MOS-SF 36 questionnaire in 79 obese patients before and after bypass gastric surgery and compared to a standard weight control group. At 1-year follow-up, available in 69% of patients, all QoL scores and depression score were improved, and better than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Weight loss and quality of life after bariatric surgery: a study of 200 patients after vertical gastroplasty or adjustable gastric banding

et al. 2007

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Background and objectives: Long term evaluation of bariatric surgery must include quality of life measurement. Methods: Quality of life (QoL) was evaluated using the original Moorehead-Ardelt questionnaire for 200 patients operated for massive obesity in a single centre between 1994 and 2003. QoL and physical data were obtained by retrospective mail questionnaire. Surgical procedures were vertical-banded gastroplasty according to Mason (VBGM) and adjustable gastric banding (AGB) in 61 and 39% of patients, respectively. The aim of the study was to assess the nutritional outcome and QoL according to the procedure. Results: Overall, the body mass index (BMI) decreased from 5078 kg/m 2 before surgery to 35.277.5 kg/m 2 at the time of the questionnaire. The percentage of weight loss was 28.8712.2%. In the group treated with VBGM, the mean initial weight (P ¼ 0.003) and the percentage of weight loss (Po0.001) were significantly higher, and the QoL was better (P ¼ 0.003) than in the group treated with AGB. On the basis of the time spent since surgery, a regular weight loss was observed during the first 5 years, whereas weight subsequently increased over the five following years. Similarly, the total QoL score gradually improved during the first 5 years and worsened thereafter. However, it remained better than before surgery. A linear regression analysis showed a positive correlation between the percentage of weight loss and the QoL score (Po0.001).Conclusions: This study suggests that the bariatric surgery, particularly the VBGM technique, improved the QoL of obese patients, at least in the first 5 years following surgery.

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A health status assessment of the impact of weight loss following Roux-en-Y gastric bypass for clinically severe obesity

Cited by 138 publications

References 25 publications

Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery

Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery

Randomized Controlled Trials of the D1/D5 Antagonist Ecopipam for Weight Loss in Obese Subjects

Weight loss and quality of life after bariatric surgery: a study of 200 patients after vertical gastroplasty or adjustable gastric banding

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