A heavy particle comparative study. Part I: depth-dose distributions

Raju, M. R.; Amols, Howard; Dicello, J.F.; Howard, J.; Lyman, John; Koehler, Andreas; Graves, R. G.; Smathers, James B.

doi:10.1259/0007-1285-51-609-699

Cited by 25 publications

(5 citation statements)

References 7 publications

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“…The three curves in the figure show the calculated survivals at three different doses of the range-modulated beam using Eqs. (5), (6) and (7). The closed circles, closed triangles and closed squares represent the surviving fractions of V79 cells at three different doses.…”

Section: Resultsmentioning

confidence: 99%

“…In 1978, Raju et al studied the biological response throughout the SOBP made by a primary ridge filter designed using limited biological data (7)(8)(9)(10). Then, in the 1980s, Blakely et al carried out comprehensive studies concerning a variety of responses of cells to several kinds of heavy ions and SOBPs (4), in which the spiral ridge filters designed by Lyman et al (11) were used.…”

Section: Introductionmentioning

confidence: 99%

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Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy

Kanai¹,

Furusawa²,

Fukutsu³

et al. 1997

Radiation Research

389

280

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Data on cellular inactivation resulting from mixed irradiation with charged-particle beams of different linear energy transfer (LET) are needed to design a spread-out Bragg peak (SOBP) for heavy-ion radiotherapy. The present study was designed to study the relationship between the physical (LET) and biological (cell killing) properties by using different monoenergetic beams of 3He, 4He and 12C ions (12 and 18.5 MeV/nucleon) and to attempt to apply the experimental data in the design of the SOBP (3 cm width) with a 135 MeV/nucleon carbon beam. Experimental studies of the physical and biological measurements using sequentially combined irradiation were carried out to establish a close relationship between LET and cell inactivation. The results indicated that the dose-cell survival relationship for the combined high- and low-LET beams could be described by a linear-quadratic (LQ) model, in which new coefficients alpha and beta for the combined irradiation were obtained in terms of dose-averaged alpha and square root of beta for the single irradiation with monoenergetic beams. Based on the relationship obtained, the actual SOBP designed for giving a uniform biological effect at 3 cm depth was tested with the 135 MeV/nucleon carbon beam. The results of measurements of both physical (LET) and biological (90% level of cell killing, etc.) properties clearly demonstrated that the SOBP successfully and satisfactorily retained its high dose localization and uniform depth distribution of the biological effect. Based on the application of these results, more useful refinement and development can be expected for the heavy-ion radiotherapy currently under way at the National Institute of Radiological Sciences, Japan.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy

Kanai¹,

Furusawa²,

Fukutsu³

et al. 1997

Radiation Research

389

280

View full text Add to dashboard Cite

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“…The dosimetry of the various heavy particle beams used in this investigation and their depth dose distributions were discussed in the first part of this series (Raju et al, 1978a). Cell-survival measurements under aerobic and hypoxic conditions for the various heavy charged-particle beams were made at the beam entrance (plateau), peak centre (10 cm wide peak), and for some of the beams at the distal peak (1 cm from dose fall-off).…”

Section: Methodsmentioning

confidence: 99%

“…The introduction to this comparative study, depthdose distributions, and cell survival as a function of depth of penetration were reported in the first two parts of this series (Raju et al, 1978a, b). The radiobiological parameters such as oxygen enhancement ratio (OER) and relative biological effectiveness (RBE) of these particles are of interest in radiotherapy.…”

mentioning

confidence: 99%

A heavy particle comparative study. Part III: OER and RBE

Raju¹,

Amols²,

Bain³

et al. 1978

BJR

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The results of a comparative study of heavy particles of interest in radiotherapy are reported in four parts. In this Part III, cell-survival measurements under aerobic and hypoxic conditions were made for various heavy particle beams. For heavy charged-particle beams, the measurements were made at the beam entrance (plateau), peak centre (10 cm wide peaks), and distal peak (1 cm from dose fall-off). Chinese hamster cells (V79) were used. Metabolic depletion was used to obtain hypoxia. The results indicate that the differences in RBE between the entrance region and peak are not very large when the Bragg peaks are broadened to 10 cm. The RBE for argon ions remains the same at the entrance and peak centre, and the RBE at the distal side of the Bragg peak is significantly reduced compared to the peak centre and entrance region because of saturation effects at high LET. The OER for protons is not significantly different from that for X rays. The OER for helium ions, carbon ions, and negative pions is larger, for neon ions is similar, and for argon ions is smaller when compared with fast neutrons. The OER values for heavy ions are higher than expected and could be due to a large delta-ray penumbra associated with the energy deposited by energetic heavy ions. The oxygen effect may depend upon energy deposition over distances of the order of nanometers.

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“…Many ion species including protons and carbon ions have been tested as candidate clinical ion beams (Kurz et al 2012, Krämer et al 2016, Sokol et al 2017, Tessonnier et al 2017, Inaniwa and Kanematsu 2018. Across many studies, carbon-ion beams have demonstrated a higher peak-to-plateau ratio than any other ion beams in the clinical energy range and the carbon-ion beams have shown high relative biological effectiveness (RBE) at the Bragg peak and its proximity even for hypoxic tumors (Raju et al 1978a, 1978b, 1978c, Hamada et al 2010, Tessonnier et al 2017. Because of these favorable physical and biological aspects, carbon ions have been selected as the most optimal ion for the ion radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Microdosimetric investigation for multi-ion therapy by means of silicon on insulator (SOI) microdosimeter

Sakata¹,

Lee²,

Tran³

et al. 2022

Phys. Med. Biol.

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[Objective] Ion radiotherapy with protons or carbon ions is one of the most advanced clinical methods for cancer treatment. To further improve the local tumor control, ion radiotherapy using multiple ion species has been investigated. Due to complexity of dose distributions delivered by multi-ion therapy in a tumor, a validation strategy for the planned treatment efficacy must be established that can be potentially used in the quality assurance (QA) protocol for the multi-ion treatment plans. In previous work, we demonstrated that the microdosimetric approach using the silicon on insulator (SOI) microdosimeter is practical for validating cell surviving fraction of MIA PaCa-2 cells in the independent fields of helium, carbon, oxygen, and neon ion beams. [Approach] This paper extends the previous study, and we demonstrate a microdosimetry based approach as a pilot study to build the QA protocol in the multi-ion therapy predicting the cell surviving fraction along the SOBP obtained by combined irradiations of He+O and C+Ne ions. Across the study, the SOI microdosimeter system MicroPlus was used for measurement of the lineal energy in individual ion fields followed by deriving the lineal energy of combined ion fields delivered by a pencil beam scanning system at HIMAC. [Main results] The predicted cell surviving fraction based on derived lineal energy and dose in the combined fields was in good agreement with the planned cell surviving fraction byour in-house treatment planning system (TPS) [Significance] The presented results indicated the potential benefit of the SOI microdosimeter system MicroPlus as the QA system in the multi-ion radiotherapy.

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A heavy particle comparative study. Part I: depth-dose distributions

Cited by 25 publications

References 7 publications

Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy

Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy

A heavy particle comparative study. Part III: OER and RBE

Microdosimetric investigation for multi-ion therapy by means of silicon on insulator (SOI) microdosimeter

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