2007
DOI: 10.1038/nature05585
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A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors

Abstract: The Drosophila melanogaster lymph gland is a haematopoietic organ1 -3 in which pluripotent blood cell progenitors proliferate and mature into differentiated haemocytes. Previous work 4 has defined three domains, the medullary zone, the cortical zone and the posterior signalling centre (PSC), within the developing third-instar lymph gland. The medullary zone is populated by a core of undifferentiated, slowly cycling progenitor cells, whereas mature haemocytes comprising plasmatocytes, crystal cells and lamelloc… Show more

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Cited by 283 publications
(614 citation statements)
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“…The niche is specified by the homeobox transcription factor Antp (29) and maintained by the early B-cell factor ortholog Collier and the endocytic protein Asrij (6,30). Collier activates JAK/STAT signaling to maintain prohemocytes.…”
Section: Discussionmentioning
confidence: 99%
“…The niche is specified by the homeobox transcription factor Antp (29) and maintained by the early B-cell factor ortholog Collier and the endocytic protein Asrij (6,30). Collier activates JAK/STAT signaling to maintain prohemocytes.…”
Section: Discussionmentioning
confidence: 99%
“…The primary lobes are separated into three functional areas: the medullary zone comprises prohemocytes, the cortical zone built up by plasmatocytes and crystal cells, and the posterior signaling center (PSC), formed by a few cells on the posterior tip of the primary lobes. The PSC halts the differentiation of the prohemocytes in the medullary zone (Mandal et al, 2007;Krzemień et al, 2007). The sessile population of hemocytes is located underneath the larval cuticle (Goto et al, 2003;Lanot et al, 2001;Zettervall et al, 2004), serving as a precursor pool for effector cells, plasmatocytes and lamellocytes in the course of the cell mediated immune response (Zettervall et al, 2004;Márkus et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…The second wave of hematopoiesis occurs at the larval stage in the lymph gland. The precursors of the lymph gland derive from the dorsal thoracic mesoderm and subsequently grow during the first and second larval instars (12)(13)(14)(15). At the third-instar larval stage, the lymph gland is the main site of hemocyte production.…”
mentioning
confidence: 99%