A hematology surveillance study of petrochemical workers exposed to benzene

Tsai, Shan P.; Fox, Erin E.; Ransdell, Jerry D; Wendt, Judy K.; Waddell, Louis C.; Donnelly, Robin

doi:10.1016/j.yrtph.2004.05.010

Cited by 35 publications

(31 citation statements)

References 20 publications

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“…Khuder et al 13 reported that blood cells, except for WBCs, decreased with 0.8 ppm benzene. However, Tsai et al ,14 Collins et al 15 and Swaen et al 16 reported no significant decrease in blood cell counts at benzene concentrations below 1 ppm. In the current study, we sought to examine the adverse effects of low benzene exposure, especially below 1 ppm, as an OEL in Korean workers.…”

Section: Introductionmentioning

confidence: 95%

The relationship between low-level benzene exposure and blood cell counts in Korean workers

et al. 2015

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improving information regarding to the work-related diseases and, more specifically, on the trend and variation of benefits paid for them. Method Through the NTEP it is possible to establish a nexus for each area of the economic activity, focusing on data of incapacitating diseases recognised by social welfare and involving more than 15 days' absence from work, using the ICD-10. Results Benefits for work-related diseases increased 128.2% during [2005][2006][2007][2008]. However, the greatest changes occurred after

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Section: Introductionmentioning

confidence: 95%

The relationship between low-level benzene exposure and blood cell counts in Korean workers

et al. 2015

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“…Benzene is also an important raw material for the manufacture of synthetic rubbers, gums, lubricants, dyes, pharmaceuticals and agricultural chemicals. In North America, Europe and Australia, workers are, nowadays, generally exposed to mean ambient levels <1 ppm (<3.25 mg/m 3 ), although higher levels of exposure are still reported (Capleton and Levy 2005;Chan et al 2006;CONCAWE 2002;Garte et al 2005;Navasumrit et al 2005;NICNAS 2001;Tsai et al 2004). European Directive 97/42/EC establishes a new limit value for the occupational exposure to benzene of 3.25 mg/m 3 (»1 ppm), eVective since 2000.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of urinary biomarkers of exposure to benzene: correlation with blood benzene and influence of confounding factors

Hoet

Smedt

Ferrari

et al. 2008

Int Arch Occup Environ Health

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At low levels of benzene exposure (<0.1 ppm), (1) t,t-MA is definitely not a reliable biomarker of benzene exposure because of the clear influence of SA originating from food, (2) SPMA and B-U reflect the internal dose with almost similar accuracies, (3) genetically based inter-individual variability in urinary excretion of biomarkers seems negligible. It remains to assess which biomarker is the best predictor of health effects.

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“…An increased inci- [76] : no difference between exposed workers and reference group. : significantly reduced level in exposed workers compared with reference group.…”

Section: Chromosomal Abnormalities In Benzene-exposed Individualsmentioning

confidence: 95%

“…For both these studies a significant dose-response relation were found. Importantly, several studies [74][75][76] also reported no decrease in blood cell counts among benzene-exposed workers or that some of the hematological parameters previously reported to be sensitive to benzene exposure, such as total number of white blood cells, neutrophils, eosinophils and monocytes, were in fact significantly increased in the exposed group compared with controls [77]. The differences in the findings of these studies could be related to the reported lower mean exposure and the use of routinely collected health surveillance data in the negative studies.…”

Section: Hematotoxicity Caused By Chronic Benzene Exposure -Bone Marrmentioning

confidence: 99%

Effects Of Benzene on Human Hematopoiesis

Kirkeleit¹,

Riise²,

Gjertsen³

et al. 2008

TOHJ

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Benzene, an aromatic hydrocarbon that is a natural component of crude oil and natural gas, is toxic to the blood and blood-forming organs. Epidemiological studies have established an association between benzene exposure and acute myeloid leukemia, and increasing evidence also indicates a possible association between benzene and multiple myeloma. A specific benzene-associated myelodysplastic syndrome has also been suggested. Chronic hematotoxic effects of benzene exposure, including reduced lymphocyte, neutrophil and platelet counts in peripheral blood, have been detected at occupational exposure below a level that had previously been considered not to cause any health effects. Whether these abnormalities represent bone marrow damage and/or initial events in the development of a true neoplastic disease is not known. Together with a reported nonlinear relationship between benzene exposure and the level of various metabolites, favoring production of biologically reactive quinones at exposure below 1 part per million, these observations suggest that benzene even at low exposure levels may contribute to the risk of acute myeloid leukemia or myelodysplastic syndrome, especially among genetically susceptible individuals.

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A hematology surveillance study of petrochemical workers exposed to benzene

Cited by 35 publications

References 20 publications

The relationship between low-level benzene exposure and blood cell counts in Korean workers

The relationship between low-level benzene exposure and blood cell counts in Korean workers

Evaluation of urinary biomarkers of exposure to benzene: correlation with blood benzene and influence of confounding factors

Effects Of Benzene on Human Hematopoiesis

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