A hemodynamic analysis of fenestrated physician-modified endograft repair for complicated aortic dissections involving the visceral arteries

Jiang, Xudong; Xiang, Guangyuan; Du, Guanting; Li, Xiaoqiang; Wu, Peng; Du, Xiaolong

doi:10.1016/j.cmpb.2023.107785

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…In previous studies, conventional hemodynamic parameters were mostly included, such as TAWSS, OSI, RRT and ECAP, which are controversial in terms of whether they can consistently and accurately reflect the possible risk of thrombosis and rupture risk of AAA. The region of low TAWSS, high OSI, high RRT and high ECAP values was generally considered to be closely related to the formation of thrombosis (Jiang et al, 2023). However, Lozowy et al (Lozowy et al, 2017) demonstrated that aneurysmal recirculation zones could have either high or low OSI and there was no correlation between OSI and ILT deposition.…”

Section: Discussionmentioning

confidence: 99%

A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model

Wang,

Jiang,

Zhang

et al. 2024

Front. Physiol.

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Objective: The aim of this study is to perform specific hemodynamic simulations of idealized abdominal aortic aneurysm (AAA) models with different diameters, curvatures and eccentricities and evaluate the risk of thrombosis and aneurysm rupture.Methods: Nine idealized AAA models with different diameters (3 cm or 5 cm), curvatures (0° or 30°) and eccentricities (centered on or tangent to the aorta), as well as a normal model, were constructed using commercial software (Solidworks; Dassault Systemes S.A, Suresnes, France). Hemodynamic simulations were conducted with the same time-varying volumetric flow rate extracted from the literature and 3-element Windkessel model (3 EWM) boundary conditions were applied at the aortic outlet. Several hemodynamic parameters such as time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), endothelial cell activation potential (ECAP) and energy loss (EL) were obtained to evaluate the risk of thrombosis and aneurysm rupture under different conditions.Results: Simulation results showed that the proportion of low TAWSS region and high OSI region increases with the rising of aneurysm diameter, whereas decreases in the curvature and eccentric models of the corresponding diameters, with the 5 cm normal model having the largest low TAWSS region (68.5%) and high OSI region (40%). Similar to the results of TAWSS and OSI, the high ECAP and high RRT areas were largest in the 5 cm normal model, with the highest wall-averaged value (RRT: 5.18 s, ECAP: 4.36 Pa−1). Differently, the increase of aneurysm diameter, curvature, and eccentricity all lead to the increase of mean flow EL and turbulent EL, such that the highest mean flow EL (0.82 W · 10−3) and turbulent EL (1.72 W · 10−3) were observed in the eccentric 5 cm model with the bending angle of 30°.Conclusion: Collectively, increases in aneurysm diameter, curvature, and eccentricity all raise mean flow EL and turbulent flow EL, which may aggravate the damage and disturbance of flow in aneurysm. In addition, it can be inferred by conventional parameters (TAWSS, OSI, RRT and ECAP) that the increase of aneurysm diameter may raise the risk of thrombosis, whereas the curvature and eccentricity appeared to have a protective effect against thrombosis.

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Section: Discussionmentioning

confidence: 99%

A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model

Wang,

Jiang,

Zhang

et al. 2024

Front. Physiol.

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Mechanisms of aortic dissection: From pathological changes to experimental and in silico models

Rolf-Pissarczyk,

Schussnig,

Fries

et al. 2025

Progress in Materials Science

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Hemodynamics of Asymmetrically Stenotic Vertebral Arteries Based on Fluid-solid Coupling

zheng,

feng,

et al. 2024

Preprint

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Stenosis in the vertebral artery, often associated with atherosclerosis, presents complexities regarding the relationship between internal resistance, shear stress and the geometric characteristics of stenosis lesions. This study aims to elucidate these relationships through computational simulations utilizing medical imaging data of human vertebral arteries. Various models representing different stenotic configurations were constructed, allowing for comprehensive analysis via Computational Fluid Dynamics (CFD) and Fluid-Structure Interaction (FSI) methods. Hemodynamic parameters such as blood flow velocity, time-averaged wall shear stress (TWASS), oscillation shear index (OSI), relative retention time (RRT), and solid mechanics indicators including total deformation and vascular Von-Mises stress were evaluated. Our findings revealed that different lesion modes had different impacts on the blood flow field in the vertebral artery. Upon comparing the mathematical model with CFD and FSI results, it was found that an augmented stenosis rate led to the creation of a watershed environment within the blood vessel, thereby expediting the onset of atherosclerosis. In cases where the vertebral artery experienced complete narrowing due to a consistent stenosis rate, there was a substantial rise in blood flow velocity. Neglecting timely intervention to alter the blood flow environment heightened the peril of triggering vascular dissection or even puncturing the blood vessel wall directly.

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A hemodynamic analysis of fenestrated physician-modified endograft repair for complicated aortic dissections involving the visceral arteries

Cited by 3 publications

References 40 publications

A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model

A hemodynamic analysis of energy loss in abdominal aortic aneurysm using three-dimension idealized model

Mechanisms of aortic dissection: From pathological changes to experimental and in silico models

Hemodynamics of Asymmetrically Stenotic Vertebral Arteries Based on Fluid-solid Coupling

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