The current research integrates, for the first-time, the relatively new and rapidly evolving disciplines of QMS, SoS, Globalization and Systems approaches such as Systems Thinking, by defining a novel field of research concerning G-QMS in global SoS organizations. This is an exploratory study which uses the Grounded Theory combined with an analytical review and professional experience to provide a framework for identifying new key variables in the multidimensional environment of global management. The purpose of this study is the creation a theoretical foundation for this field of research, and introduce logical deductions regarding G-QMS in global SoS organizations that can be used as foundational principles for a definition and model of G-QMS. Methodology: The study paradigm combines analytical review, which integrates the four main disciplines, and a structured qualitative study based on semi-structured interviews, and used Grounded Theory. Results and conclusions: The findings show that G-QMS is a necessary condition for these organizations, while the management of G-QMS is inseparable from the management of the SoS. The final results reveal 18 aspects to be considered in any definition determined for G-QMS in global SoS organizations, and any model to be developed. From these, 8 base anchors for the model were analyzed and mapped, as well as its main factors. Each of these base anchors makes its own contribution to any further development in this area. However, considering them all together creates an initial model of G-QMS in global SoS organizations.